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Yiwei Zhao
Researcher at University of Dundee
Publications - 25
Citations - 7157
Yiwei Zhao is an academic researcher from University of Dundee. The author has contributed to research in topics: Filaggrin & Atopic dermatitis. The author has an hindex of 20, co-authored 25 publications receiving 6694 citations.
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Journal ArticleDOI
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Colin N. A. Palmer,Alan D. Irvine,Ana Terron-Kwiatkowski,Yiwei Zhao,Haihui Liao,Simon P. Lee,David Goudie,Aileen Sandilands,Linda E. Campbell,Frances J.D. Smith,Grainne M. O'Regan,Rosemarie Watson,Jo E Cecil,Sherri J. Bale,John G. Compton,John J. DiGiovanna,John J. DiGiovanna,Philip Fleckman,Sue Lewis-Jones,Gehan Arseculeratne,Ann Sergeant,Colin S. Munro,Brahim El Houate,Ken McElreavey,Liselotte Brydensholt Halkjaer,Hans Bisgaard,Somnath Mukhopadhyay,Somnath Mukhopadhyay,W.H. Irwin McLean +28 more
TL;DR: It is shown that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis.
Journal ArticleDOI
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Frances J.D. Smith,Alan D. Irvine,Ana Terron-Kwiatkowski,Aileen Sandilands,Linda E. Campbell,Yiwei Zhao,Haihui Liao,Alan Evans,David Goudie,Sue Lewis-Jones,Gehan Arseculeratne,Colin S. Munro,Ann Sergeant,Grainne M. O'Regan,Sherri J. Bale,John G. Compton,John J. DiGiovanna,John J. DiGiovanna,Richard B. Presland,Philip Fleckman,W.H. Irwin McLean +20 more
TL;DR: It is found that loss or reduction of this major structural protein, filaggrin, leads to varying degrees of impaired keratinization.
Journal ArticleDOI
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.
Aileen Sandilands,Ana Terron-Kwiatkowski,Peter R. Hull,Grainne M. O'Regan,Timothy H Clayton,Rosemarie Watson,Thomas Carrick,Alan Evans,Haihui Liao,Yiwei Zhao,Linda E. Campbell,Matthias Schmuth,Robert Gruber,Andreas R. Janecke,Peter M. Elias,Maurice A.M. van Steensel,Ivo F Nagtzaam,Michel van Geel,Peter M. Steijlen,Colin S. Munro,Daniel G. Bradley,Colin N. A. Palmer,Frances J.D. Smith,W.H. Irwin McLean,Alan D. Irvine,Alan D. Irvine +25 more
TL;DR: It is shown that the common filaggrin (FLG) null mutations that cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases are ancestral variants carried on conserved haplotypes, and a strategy for full sequencing of this large, highly repetitive gene is reported.
Journal ArticleDOI
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
Stephan Weidinger,Thomas Illig,Hansjörg Baurecht,Alan D. Irvine,Elke Rodriguez,Amalia Diaz-Lacava,Norman Klopp,Stefan Wagenpfeil,Yiwei Zhao,Haihui Liao,Simon P. Lee,Colin N. A. Palmer,Claudia Jenneck,Laura Maintz,Tobias Hagemann,Heidrun Behrendt,Johannes Ring,Markus M. Nöthen,W.H. Irwin McLean,Natalija Novak +19 more
TL;DR: In this article, a family-based approach revealed prominent associations between the 2 loss-of-function FLG mutations and AD, as previously observed in a traditional Mendelian linkage analysis and case-control cohort analysis approach.
Journal ArticleDOI
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
Sara J. Brown,Sara J. Brown,Sara J. Brown,Yuka Asai,Heather J. Cordell,Linda E. Campbell,Yiwei Zhao,Haihui Liao,Kate Northstone,John Henderson,Reza Alizadehfar,Moshe Ben-Shoshan,Kenneth Morgan,Graham Roberts,Laury J.N. Masthoff,Suzanne G.M.A. Pasmans,Peter C. van den Akker,Cisca Wijmenga,Jonathan O'b Hourihane,Colin N. A. Palmer,Gideon Lack,Ann E. Clarke,Peter R. Hull,Alan D. Irvine,Alan D. Irvine,W.H. Irwin McLean +25 more
TL;DR: Filaggrin mutations represent a significant risk factor for IgE-mediated peanut allergy, indicating a role for epithelial barrier dysfunction in the pathogenesis of this disease.