S
Simon Young
Researcher at University of Texas Health Science Center at Houston
Publications - 67
Citations - 4203
Simon Young is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Bone regeneration & Medicine. The author has an hindex of 23, co-authored 57 publications receiving 3486 citations. Previous affiliations of Simon Young include University of Texas System & Harvard University.
Papers
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Journal ArticleDOI
Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model.
Xuan Guo,Hansoo Park,Simon Young,James D. Kretlow,Jeroen J.J.P. van den Beucken,L. Scott Baggett,Yasuhiko Tabata,F. Kurtis Kasper,Antonios G. Mikos,John A. Jansen +9 more
TL;DR: While OPF-based hydrogel composites supported osteochondral tissue generation, further investigations are necessary to elucidate the effects of MSC seeding density and differentiation stage on new tissue formation and regeneration.
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STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy
David G. Leach,Neeraja Dharmaraj,Stacey L. Piotrowski,Tania L. Lopez-Silva,Yu Lei,Andrew G. Sikora,Simon Young,Jeffrey D. Hartgerink +7 more
TL;DR: STINGel is an injectable peptide hydrogel that localizes and provides controlled release of CDN delivery, and dramatically improves overall survival in a challenging murine model of head and neck cancer compared to CDN alone or CDN delivered from a collagen hydrogels.
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Advances in immunotherapy delivery from implantable and injectable biomaterials
TL;DR: The first pioneering efforts and most recent advances in biomaterials for immunotherapeutic applications are explored, with a specific focus on implantable and injectable biommaterials such as porous scaffolds, cryogels, and hydrogels.
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Antibiotic-releasing Porous Polymethylmethacrylate Constructs for Osseous Space Maintenance and Infection Control
Meng Shi,James D. Kretlow,Anson Nguyen,Simon Young,Simon Young,L. Scott Baggett,Mark E. Wong,F. Kurtis Kasper,Antonios G. Mikos +8 more
TL;DR: Information is provided on the composition parameters that enable viable porosity characteristics/drug release kinetics of the PMMA/CMC/PLGA construct for the initial space maintenance as part of a two-stage regenerative medicine approach.
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Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine.
Yee Sun Tan,Kanokwan Sansanaphongpricha,Yuying Xie,Christopher R. Donnelly,Xiaobo Luo,Xiaobo Luo,Blake R. Heath,Xinyi Zhao,Emily Bellile,Hongxiang Hu,Hongwei Chen,Peter J. Polverini,Qianming Chen,Simon Young,Thomas E. Carey,Jacques E. Nör,Robert L. Ferris,Gregory T. Wolf,Duxin Sun,Yu Lei +19 more
TL;DR: The nanosatellite vaccine offers a novel and effective approach to enhance the adjuvant potential of STING agonist and break cancer tolerance to immunotherapy.