S
Simona Simmen
Researcher at University of Zurich
Publications - 4
Citations - 242
Simona Simmen is an academic researcher from University of Zurich. The author has contributed to research in topics: Inflammation & Hypoxia (medical). The author has an hindex of 3, co-authored 4 publications receiving 148 citations.
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Journal ArticleDOI
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.
Jesus Cosin-Roger,Simona Simmen,Hassan Melhem,Kirstin Atrott,Isabelle Frey-Wagner,Martin Hausmann,Cheryl de Valliere,Marianne R. Spalinger,Patrick Spielmann,Roland H. Wenger,Jonas Zeitz,Stephan R. Vavricka,Gerhard Rogler,Pedro A. Ruiz +13 more
TL;DR: Hypoxia is shown to ameliorate intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy, and it is suggested that hypoxia counteracts inflammation through the downregulation of the binding of mTOR and NLRP3 and activation of Autophagy.
Journal ArticleDOI
Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
Cheryl de Valliere,Jesus Cosin-Roger,Jesus Cosin-Roger,Simona Simmen,Kirstin Atrott,Hassan Melhem,Jonas Zeitz,Mehdi Madanchi,Irina Tcymbarevich,Michael Fried,Gerd A. Kullak-Ublick,Stephan R. Vavricka,Benjamin Misselwitz,Klaus Seuwen,Carsten A. Wagner,Jyrki J. Eloranta,Gerhard Rogler,Pedro A. Ruiz +17 more
TL;DR: The enhancement of TNF- and hypoxia-induced OGR1 expression under low pH points to a positive feed-forward regulation of O GR1 activity in acidic conditions, and supports a role for OGR 1 in the pathogenesis of IBD.
Journal ArticleDOI
Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium.
Simona Simmen,Jesus Cosin-Roger,Hassan Melhem,Nikolaos Maliachovas,Max Maane,Katharina Baebler,Bruce Weder,Chiaki Maeyashiki,Katharina Spanaus,Michael Scharl,Cheryl de Valliere,Jonas Zeitz,Stephan R. Vavricka,Martin Hausmann,Gerhard Rogler,Pedro A. Ruiz +15 more
TL;DR: Hypoxia promotes iron mobilization from the intestinal epithelium and reduces inflammatory processes in HT-29 cells, and iron mobilization into enterocytes may be a vital protective mechanism in the hypoxic inflamed mucosa.
Journal ArticleDOI
Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa
Simona Simmen,Max Maane,Sarah Rogler,Katherina Baebler,Silvia Lang,Jesus Cosin-Roger,Kirstin Atrott,Isabelle Frey-Wagner,Partick Spielmann,Roland H. Wenger,Bruce Weder,Jonas Zeitz,Stephan R. Vavricka,Gerhard Rogler,Cheryl de Valliere,Martin Hausmann,Pedro A. Ruiz +16 more
TL;DR: Stabilization of hypoxia-inducible factors might represent a novel therapeutic approach for the treatment of IBD-associated fibrosis.