Jonas Zeitz

TL;DR: EIMs are a frequent problem in CD and UC patients and identification of EIM prevalence and associated risk factors may result in increased awareness for this problem and thereby facilitating their diagnosis and therapeutic management.

TL;DR: The results indicate that smoking is an environmental factor modulating the composition of human gut microbiota, suggesting a potential pathogenetic link between weight gain and smoking cessation and giving rise to a potential association of smoking status and the course of IBD.

TL;DR: A significant association between symptoms of depression or anxiety and clinical recurrence of inflammatory bowel disease is found and patients with IBD should be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.

TL;DR: Hypoxia is shown to ameliorate intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy, and it is suggested that hypoxia counteracts inflammation through the downregulation of the binding of mTOR and NLRP3 and activation of Autophagy.

TL;DR: It is confirmed that intestinal microbiota composition in humans is influenced by smoking, and the characteristics of observed microbial shifts suggest a potential mechanistic association to alterations in body weight subsequent to smoking cessation.