Simona Suardi

TL;DR: The molecular and clinical results are in agreement with previous findings but provide additional information into the biologic mechanisms involved in HR-HPV oropharyngeal cancer in comparison to HPV-negative tumors.

TL;DR: The APC-β-catenin pathway is inactivated in MIN− SCRCs and represents the first hit of SCRC development, and molecular characterization can be translated into a clinical setting to improve diagnosis and to direct a rationale pharmacological treatment.

TL;DR: The p16/ARFΔ+BRAF/RAS profile was significantly associated with a longer survival, while complex mutational profiles were detected in highly aggressive disease and poor survival, suggesting that a more extensive molecular classification of melanoma would significantly impact its clinical management.

TL;DR: The findings suggest that assessing HPV, TP53, 9p21, and EGFR status may be crucial to finding more tailored and beneficial treatments for oropharyngeal SCCs.

TL;DR: The results indicate the existence of two genetic ITAC subgroups, defined by differences in TP53 mutational status or protein functionality, that strongly influence pathologic response to primary chemotherapy and, ultimately, prognosis.