Simone Dusseljee

TL;DR: It is shown that RILP prevents further cycling of Rab7 and induces the recruitment of functional dynein-dynactin motor complexes to Rab7-containing late endosomes and lysosomes.

TL;DR: This work visualizes rapid movement of acidic class II/beta- GFP containing vesicles from lysosomal compartments to the plasma membrane and shows that fusion of these vesicle with the plasma membranes occurs and that this transport route does not intersect the earlier endosomal pathway.

TL;DR: It is proposed that the wortmannin-induced vacuolation occurs as a result of the inability of multivesicular bodies to store endocytosed membranes as intraluminal vesicles thereby causing the formation of large 'empty' vacuoles.

TL;DR: This work has visualised vesicular transport of MHC class II-containing early lysosomes from the microtubule organising centre (MTOC) region towards the cell surface in living cells and shows that the MIIC move bidirectionally in a 'stop-and-go' fashion.

TL;DR: It is shown here that continuous protein synthesis is required for the maintenance of MIIC in B cells and that expression of class II molecules is sufficient to induce the formation of characteristic MIIC-like multilaminar structures.