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Ingrid Jordens
Researcher at Utrecht University
Publications - 28
Citations - 4134
Ingrid Jordens is an academic researcher from Utrecht University. The author has contributed to research in topics: Wnt signaling pathway & Endosome. The author has an hindex of 17, co-authored 25 publications receiving 3612 citations. Previous affiliations of Ingrid Jordens include Netherlands Cancer Institute & Cornell University.
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Journal ArticleDOI
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Bon-Kyoung Koo,Maureen Spit,Ingrid Jordens,Teck Yew Low,Daniel E. Stange,Marc van de Wetering,Johan H. van Es,Shabaz Mohammed,Albert J. R. Heck,Madelon M. Maurice,Hans Clevers +10 more
TL;DR: It is concluded that RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation.
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The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors
Ingrid Jordens,Mar Fernandez-Borja,Marije Marsman,Simone Dusseljee,Lennert Janssen,Jero Calafat,Hans Janssen,Richard Wubbolts,Jacques Neefjes +8 more
TL;DR: It is shown that RILP prevents further cycling of Rab7 and induces the recruitment of functional dynein-dynactin motor complexes to Rab7-containing late endosomes and lysosomes.
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Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin
Marie Johansson,Nuno Rocha,Wilbert Zwart,Ingrid Jordens,Lennert Janssen,Coenraad Kuijl,Vesa M. Olkkonen,Jacques Neefjes +7 more
TL;DR: The results illustrate that the assembly of microtubule motors on endosomes involves a cascade of linked events, and Rab7 recruits two effectors, RILP and ORP1L, to form a tripartite complex.
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Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
Henner F. Farin,Ingrid Jordens,Mohammed H. Mosa,Mohammed H. Mosa,Onur Basak,Jeroen Korving,Daniele V.F. Tauriello,Karin de Punder,Stephane Angers,Peter J. Peters,Madelon M. Maurice,Hans Clevers +11 more
TL;DR: It is concluded that stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and ‘plasma membrane dilution’ through cell division shape the epithelial Wnt3 gradient.
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Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Sonja Krugmann,Ingrid Jordens,Kris Gevaert,Mariëtte H.E. Driessens,Joël Vandekerckhove,Alan Hall +5 more
TL;DR: It is concluded that the interaction of Cdc42 with the partial CRIB motif of IRSp53 relieves an intramolecular, autoinhibitory interaction with the N terminus, allowing the recruitment of Mena to theIRSp53 SH3 domain.