S
Simone M. Costa
Researcher at Oswaldo Cruz Foundation
Publications - 35
Citations - 1387
Simone M. Costa is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Dengue virus & DNA vaccination. The author has an hindex of 19, co-authored 33 publications receiving 1259 citations. Previous affiliations of Simone M. Costa include Instituto Nacional de Medicina Legal & Federal University of Rio de Janeiro.
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Journal ArticleDOI
Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ)
Valéria Freitas de Magalhães,Marcelo Manzi Marinho,Patrícia Domingos,Ariclécio Cunha de Oliveira,Simone M. Costa,Luiz Otávio Azevedo,Sandra M.F.O. Azevedo +6 more
TL;DR: It was verified that 19% of the animals' samples were above the limit recommended by WHO for human consumption, which refers to healthy adult, and data demonstrate that, although in low concentrations, there is already a contamination of fish and crustaceans from Sepetiba Bay.
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Occurrence of toxin-producing cyanobacteria blooms in a Brazilian semiarid reservoir
I. A. S. Costa,Sandra M.F.O. Azevedo,P. A. C. Senna,R. R. Bernardo,Simone M. Costa,N. T. Chellappa +5 more
TL;DR: The occurrence of toxic blooms in this reservoir points to a permanent risk of cyanotoxins in supply waters, indicating the need for the implementation of bloom control measures to improve the water quality.
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Liver injury and viremia in mice infected with dengue-2 virus
Marciano Viana Paes,Angela Teixeira Pinhão,Débora Ferreira Barreto,Simone M. Costa,M.P. Oliveira,Ana Cristina Martins de Almeida Nogueira,Christina Maeda Takiya,José da Costa Farias-Filho,Hermann G. Schatzmayr,Ada M. B. Alves,Ortrud Monika Barth +10 more
TL;DR: Testing the feasibility of BALB/c mice as an experimental model in the study of dengue disease revealed liver injury with viral antigens detection, and data correlate to the development of the disease described in humans.
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Lutzomyia (Nyssomyia) whitmani s.l . (Antunes & Coutinho, 1939)(Diptera: Psychodidae: Phlebotominae): geographical distribution and the epidemiology of American cutaneous leishmaniasis in Brazil Mini-review
Simone M. Costa,Michela Cechinel,Valdenir Bandeira,José C Zannuncio,Ralph Lainson,Elizabeth F. Rangel +5 more
TL;DR: The distribution of Lutzomyia (Nyssomyia) whitmani s.l. in Brazil is investigated to investigate the distribution of this sand fly species and American cutaneous leishmaniasis (ACL) in relationship to vegetation and landscape ecology throughout Brazil.
Journal ArticleDOI
DNA vaccines against dengue virus based on the ns1 gene: the influence of different signal sequences on the protein expression and its correlation to the immune response elicited in mice.
Simone M. Costa,Adriana de Souza Azevedo,Marciano Viana Paes,F.S. Sarges,Marcos da Silva Freire,Ada M. B. Alves +5 more
TL;DR: Protection against DENV-2 was verified in pcTPANS1- and pcENS1-immunized mice, although the plasmid pcTPans1 induced slight higher protective immunity, and these plasmids seem to activate distinct patterns of the immune system.