Simone Moertl

TL;DR: It is shown that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2).

TL;DR: A functional role of exosome in the response of tumor cells to radiation exposure within a therapeutic dose range is indicated and encourages that exosomes are useful objects of study for a better understanding of tumor radiation response.

TL;DR: Strong evidence is found that the circulating therapy-responsive miRNAs are tumour related and were able to validate them in an independent cohort of HNSCC patients.

TL;DR: It is demonstrated that exosomes derived from irradiated HNSCC cells confer a migratory phenotype to recipient cancer cells, possibly due to radiation-regulated exosomal proteins that increase AKT-signalling.

TL;DR: These data suggest that neurocognitive disorders may be induced in adults when exposed at a young age to low and moderate cranial doses of radiation, which raises concerns about radiation safety standards and regulatory practices.