Simone Silberman

TL;DR: The inhibition of lung colonization in C57BL/6 mice by rTIMP is one of the first examples showing an antimetastatic effect of a selective metalloproteinase inhibitor in a mammalian animal model, and supports an essential role for metalliproteinase(s) in the extravasation and invasion of tumor cells during lung colonization by blood-borne tumor cells.

TL;DR: Centrifugation of oxygenator contents was found to be safe, sterile, and effective in concentrating red cells without damage and serves as a means of minimizing the consequences of fluid overload after cardiopulmonary bypass.

TL;DR: It is concluded that high ERK activity is required for both protease Phenotypes, whereas the JNK pathway and c-Jun/AP-1 activity are not required for transformation but regulate a switch between uPA and CL protease phenotypes in both transformed and untransformed cells.

TL;DR: The JNK pathway acts as a switch between two distinct protease phenotypes that are redundant in their abilities to grow tumors and metastasize.

TL;DR: Serial cytogenetic studies using banding techniques at various stages during the course of the disease showed several chromosomal abnormalities (unbalanced translocation between chromosomes 1 and 4 leading to trisomy 1q,trisomy 7q, monosomy 7p, and a reciprocal translocated between chromosomes 10 and 16).