S
Sina Ghaemmaghami
Researcher at University of Rochester
Publications - 62
Citations - 11237
Sina Ghaemmaghami is an academic researcher from University of Rochester. The author has contributed to research in topics: Proteome & Protein turnover. The author has an hindex of 24, co-authored 55 publications receiving 10170 citations. Previous affiliations of Sina Ghaemmaghami include California Institute for Quantitative Biosciences & University of California, San Francisco.
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Journal ArticleDOI
Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain.
Yi Lin,Xiaoming Zhou,Masato Kato,Daifei Liu,Sina Ghaemmaghami,Benjamin P. Tu,Steven L. McKnight +6 more
TL;DR: Evidence is presented that the low complexity domain of TDP43 self-associates into a specific structural conformation that may be important to its normal biological function, including facilitating synapse-localized translation as well as aberrant aggregation of the protein in neurodegenerative diseases.
Journal ArticleDOI
Proteome-wide modulation of degradation dynamics in response to growth arrest
Tian Zhang,Clara Wolfe,Andrew Pierle,Kevin A. Welle,Jennifer R. Hryhorenko,Sina Ghaemmaghami +5 more
TL;DR: It is demonstrated that fibroblasts selectively increase degradation rates of long-lived proteins as they transition from a proliferating to a quiescent state, by the concurrent activation of lysosomal biogenesis and up-regulation of macroautophagy.
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A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.
G. Poncet-Montange,Susan J. St. Martin,Olga V. Bogatova,Stanley B. Prusiner,Brian K. Shoichet,Sina Ghaemmaghami +5 more
TL;DR: It is suggested that in comparison to PrP conformers themselves, proteins that play auxiliary roles in prion propagation may be more effective targets for future drug discovery efforts.
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Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.
Misol Ahn,Sina Ghaemmaghami,Yong Huang,Puay-Wah Phuan,Barnaby C. H. May,Kurt Giles,Stephen J. DeArmond,Stanley B. Prusiner +7 more
TL;DR: It is argued that the inhibition of the P-gp efflux transporter should improve the poor pharmacokinetic properties of quinacrine in the CNS.
Journal ArticleDOI
Global analysis of cellular protein flux quantifies the selectivity of basal autophagy.
Tian Zhang,Sina Ghaemmaghami +1 more
TL;DR: The methodology outlined in the study provides a global strategy for quantifying the selectivity of basal macroautophagy and indicates that in quiescent fibroblasts, macroautophile contributes to the basal turnover of a substantial fraction of the proteome.