S
Sina Ghaemmaghami
Researcher at University of Rochester
Publications - 62
Citations - 11237
Sina Ghaemmaghami is an academic researcher from University of Rochester. The author has contributed to research in topics: Proteome & Protein turnover. The author has an hindex of 24, co-authored 55 publications receiving 10170 citations. Previous affiliations of Sina Ghaemmaghami include California Institute for Quantitative Biosciences & University of California, San Francisco.
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Journal ArticleDOI
Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome
Ethan J. Walker,Ethan J. Walker,John Bettinger,Kevin A. Welle,Jennifer R. Hryhorenko,Sina Ghaemmaghami,Sina Ghaemmaghami +6 more
TL;DR: A highly multiplexed proteomics approach based on analyses of methionine oxidation rates is used to quantify stabilities of ∼10,000 unique regions within ∼3,000 proteins in human cell extracts and identifies lysosomal and extracellular proteins as the most stable ontological subsets of the proteome.
Journal ArticleDOI
Conformational transformation and selection of synthetic prion strains
Sina Ghaemmaghami,Joel C. Watts,Hoang-Oanh B. Nguyen,Shigenari Hayashi,Stephen J. DeArmond,Stanley B. Prusiner +5 more
TL;DR: It is demonstrated that prions can exist as a conformationally diverse population of strains, each capable of replicating with high fidelity, and rare conformational conversion, followed by competitive selection among the resulting pool of conformers, provides a mechanism for the adaptation of the prion population to its host environment.
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Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice
Karah Nazor Friberg,Gene Hung,Ed Wancewicz,Kurt Giles,Chris Black,Sue Freier,Frank C. Bennett,Stephen J. DeArmond,Yevgeniy Freyman,Pierre Lessard,Sina Ghaemmaghami,Stanley B. Prusiner +11 more
TL;DR: Whether ASOs can be used to develop an effective therapy for patients dying of Creutzfeldt–Jakob disease remains to be established.
Journal ArticleDOI
Folding kinetics of a fluorescent variant of monomeric lambda repressor.
TL;DR: A tryptophan-containing variant of monomeric λ repressor has been made, and its folding kinetics were analyzed at 20 °C using fluorescence stopped-flow and dynamic NMR as mentioned in this paper.
Journal ArticleDOI
Cross-species Comparison of Proteome Turnover Kinetics.
Kyle Swovick,Kevin A. Welle,Jennifer R. Hryhorenko,Andrei Seluanov,Vera Gorbunova,Sina Ghaemmaghami +5 more
TL;DR: By reducing the energetic demands of continuous protein turnover, long-lived species may have evolved to lessen the generation of reactive oxygen species and the corresponding oxidative damage over their extended lifespans.