S
Sinisa D. Grozdanic
Researcher at Iowa State University
Publications - 49
Citations - 1747
Sinisa D. Grozdanic is an academic researcher from Iowa State University. The author has contributed to research in topics: Glaucoma & Optic nerve. The author has an hindex of 24, co-authored 47 publications receiving 1582 citations. Previous affiliations of Sinisa D. Grozdanic include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
Gulab Zode,Markus H. Kuehn,Darryl Y. Nishimura,Charles Searby,Kabhilan Mohan,Sinisa D. Grozdanic,Kevin Bugge,Michael G. Anderson,Abbot F. Clark,Edwin M. Stone,Val C. Sheffield +10 more
TL;DR: Reduction of ER stress with a chemical chaperone, phenylbutyric acid (PBA), prevented glaucoma phenotypes in Tg-MYOC(Y437H) mice by promoting the secretion of mutant myocilin in the aqueous humor and by decreasing intracellular accumulation of myociles in the ER, thus preventing TM cell death.
Journal ArticleDOI
Retinal synthesis and deposition of complement components induced by ocular hypertension.
Markus H. Kuehn,Chan Yun Kim,Jelena Ostojić,Micheal Bellin,Wallace L.M. Alward,Edwin M. Stone,Donald S. Sakaguchi,Sinisa D. Grozdanic,Young H. Kwon +8 more
TL;DR: The results show that complement activation occurs in the retina that has been subjected to elevated IOP, and may have implications in pathophysiology of glaucoma.
Journal ArticleDOI
Transplantation of BDNF-Secreting Mesenchymal Stem Cells Provides Neuroprotection in Chronically Hypertensive Rat Eyes
Matthew M. Harper,Sinisa D. Grozdanic,Bas Blits,Markus H. Kuehn,Daniel Zamzow,Janice E. Buss,Randy H. Kardon,Randy H. Kardon,Donald S. Sakaguchi,Donald S. Sakaguchi +9 more
TL;DR: It is demonstrated that lentiviral-transduced BDNF-producing MSCs can survive in eyes with chronic hypertension and can provide retina and optic nerve functional and structural protection and may be a viable treatment strategy for glaucoma.
Journal ArticleDOI
Laser-Induced Mouse Model of Chronic Ocular Hypertension
Sinisa D. Grozdanic,Daniel M. Betts,Donald S. Sakaguchi,Rachell A. Allbaugh,Young H. Kwon,Randy H. Kardon +5 more
TL;DR: Diode laser treatment of ICG saturated episcleral veins causes a chronic elevation of IOP and sustained ERG deficits in surgical eyes and Histologic analysis of the surgical eyes revealed development of anterior synechia, loss of retinal ganglion cells (RGCs), and thinning of all retinal layers.
Journal ArticleDOI
Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma
Gulab Zode,Kevin Bugge,Kabhilan Mohan,Sinisa D. Grozdanic,Joseph C. Peters,Demelza Koehn,Michael G. Anderson,Randy H. Kardon,Randy H. Kardon,Edwin M. Stone,Edwin M. Stone,Val C. Sheffield,Val C. Sheffield +12 more
TL;DR: Topical ocular PBA could become a novel treatment for POAG patients with myocilin mutations, most likely by reducing myOCilin accumulation and ER stress in the TM of Tg-MYOC(Y437H) mice.