G
Gulab Zode
Researcher at University of North Texas Health Science Center
Publications - 34
Citations - 1964
Gulab Zode is an academic researcher from University of North Texas Health Science Center. The author has contributed to research in topics: Trabecular meshwork & Glaucoma. The author has an hindex of 18, co-authored 29 publications receiving 1538 citations. Previous affiliations of Gulab Zode include University of North Texas & Howard Hughes Medical Institute.
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Journal ArticleDOI
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
Gulab Zode,Markus H. Kuehn,Darryl Y. Nishimura,Charles Searby,Kabhilan Mohan,Sinisa D. Grozdanic,Kevin Bugge,Michael G. Anderson,Abbot F. Clark,Edwin M. Stone,Val C. Sheffield +10 more
TL;DR: Reduction of ER stress with a chemical chaperone, phenylbutyric acid (PBA), prevented glaucoma phenotypes in Tg-MYOC(Y437H) mice by promoting the secretion of mutant myocilin in the aqueous humor and by decreasing intracellular accumulation of myociles in the ER, thus preventing TM cell death.
Journal ArticleDOI
Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for Glaucoma
Robert J. Wordinger,Debra L. Fleenor,Peggy E. Hellberg,Iok-Hou Pang,Tara O. Tovar,Gulab Zode,John A. Fuller,Abbot F. Clark +7 more
TL;DR: Results from this study are consistent with the hypothesis that, in POAG, elevated expression of Gremlin by TM cells inhibits BMP-4 antagonism of TGF-beta2 and leads to increased ECM deposition and elevated IOP.
Journal ArticleDOI
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture
Kate E. Keller,Sanjoy K. Bhattacharya,Theresa Borrás,Thomas M. Brunner,Sunee Chansangpetch,Abbott F. Clark,W. Michael Dismuke,Yiqin Du,Michael H. Elliott,C. Ross Ethier,Jennifer A. Faralli,Thomas F. Freddo,Rudolf Fuchshofer,Michael Giovingo,Haiyan Gong,Pedro Gonzalez,Alex S. Huang,Murray A. Johnstone,Paul L. Kaufman,Mary J. Kelley,Paul A. Knepper,Casey Kopczynski,John Kuchtey,Rachel W. Kuchtey,Markus H. Kuehn,Raquel L. Lieberman,Shan C. Lin,Paloma B. Liton,Yutao Liu,Elke Lütjen-Drecoll,Weiming Mao,Marisse Masis-Solano,Fiona McDonnell,Colleen M McDowell,Darryl R. Overby,Padmanabhan P. Pattabiraman,Vijay Krishna Raghunathan,P. Vasanth Rao,Douglas J Rhee,Uttio Roy Chowdhury,Paul Russell,John R. Samples,Donald Schwartz,Evan B. Stubbs,Ernst R. Tamm,James C. Tan,Carol B. Toris,Karen Y. Torrejon,Janice A. Vranka,Mary K. Wirtz,Thomas Yorio,Jie Zhang,Gulab Zode,Michael P. Fautsch,Donna M. Peters,Ted S. Acott,W. Daniel Stamer +56 more
TL;DR: Having a set of standard practices for TM cells will increase the scientific rigor when used as a model, and enable other researchers to replicate and build upon previous findings.
Journal ArticleDOI
Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain.
Jonathan M. Beckel,Jonathan M. Beckel,Arthur J. Argall,Jason C. Lim,Jingsheng Xia,Wennan Lu,Erin E. Coffey,Edward J. Macarak,Mohammed Shahidullah,Nicholas A. Delamere,Gulab Zode,Val C. Sheffield,Valery I. Shestopalov,Valery I. Shestopalov,Alan M. Laties,Claire H. Mitchell +15 more
TL;DR: Astrocytes released ATP in response to mechanical strain, with pannexin 1 the predominant efflux pathway, and sustained strain upregulated pannexins in vitro and in vivo, providing a mechanism by which extracellular ATP remains elevated under chronic mechanical strain.
Journal ArticleDOI
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma
Gulab Zode,Arti B. Sharma,Xiaolei Lin,Charles Searby,Kevin Bugge,Gunhee Kim,Abbot F. Clark,Val C. Sheffield +7 more
TL;DR: The data indicate that ER stress contributes to glucocorticoid-induced ocular hypertension and suggest that reducing ER stress has potential as a therapeutic strategy for treating glaucoma.