S
SJ Vastert
Researcher at Utrecht University
Publications - 22
Citations - 377
SJ Vastert is an academic researcher from Utrecht University. The author has contributed to research in topics: Arthritis & Systemic-onset juvenile idiopathic arthritis. The author has an hindex of 6, co-authored 19 publications receiving 259 citations.
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Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis: the SHARE initiative
Tamás Constantin,Ivan Foeldvari,Jordi Anton,Joke H. de Boer,Severine Czitrom-Guillaume,Clive Edelsten,Raz Gepstein,Arnd Heiligenhaus,Clarissa Pilkington,Gabriele Simonini,Yosef Uziel,SJ Vastert,Nico M Wulffraat,Anne Mieke J.W. Haasnoot,Karoline Walscheid,Annamária Pálinkás,Reshma Pattani,Zoltán Györgyi,Richárd Kozma,Victor Boom,Andrea Ponyi,Angelo Ravelli,Athimalaipet V Ramanan +22 more
TL;DR: Recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated by an evidence-informed consensus process to suggest a standard of care for Jia-associated Uveitis patients throughout Europe.
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PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
Alessandra Petrelli,Gerdien Mijnheer,David P. Hoytema van Konijnenburg,David P. Hoytema van Konijnenburg,Maria M. van der Wal,Barbara Giovannone,Enric Mocholi,Nadia Vazirpanah,Jasper C A Broen,DirkJan Hijnen,Bas Oldenburg,Paul J. Coffer,SJ Vastert,Berent J. Prakken,Eric Spierings,Aridaman Pandit,Michal Mokry,Michal Mokry,Femke van Wijk +18 more
TL;DR: It is shown that local chronic inflammation drives the induction and expansion of CD8+ T cells endowed with potential detrimental properties, which lays the basis for investigation of PD-1–expressing CD8- T cell targeting strategies in human chronic inflammatory diseases.
Journal ArticleDOI
Evidence-based diagnosis and treatment of macrophage activation syndrome in systemic juvenile idiopathic arthritis
Victor Boom,Jordi Anton,Pekka Lahdenne,Pierre Quartier,Angelo Ravelli,NM Wulffraat,SJ Vastert +6 more
TL;DR: MAS in sJIA seems to be diagnosed best by the recently proposed PRINTO criteria, although prospective validation is needed, and no validated diagnostic criteria for MAS in s JIA is confirmed.
Journal ArticleDOI
Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy.
Janneke G. C. Peeters,L W Picavet,S G J M Coenen,Mario Mauthe,Stephin J. Vervoort,E Mocholi,C. de Heus,Judith Klumperman,SJ Vastert,Fulvio Reggiori,P. J. Coffer,Michal Mokry,J van Loosdregt +12 more
TL;DR: Analysis of genome-wide transcriptomic and epigenomic profiling after nutrient deprivation in human autophagy-proficient and autophagic-deficient cells stresses the relevance of transcriptional and epigenetic regulation of autophile regulation and can be used as a resource to identify (novel) factors involved in Autophagy regulation.
Journal ArticleDOI
Self-Sustained Resistance to Suppression of CD8+ Teff Cells at the Site of Autoimmune Inflammation Can Be Reversed by Tumor Necrosis Factor and Interferon-γ Blockade.
Alessandra Petrelli,Ellen J. Wehrens,Rianne C. Scholman,Berent J. Prakken,SJ Vastert,Femke van Wijk +5 more
TL;DR: Investigation of intrinsic resistance of CD8+ Teff cells to suppression is investigated to determine how this can be targeted therapeutically and whether this resistant phenotype is self‐sustained.