J
Jasper C A Broen
Researcher at Utrecht University
Publications - 47
Citations - 2115
Jasper C A Broen is an academic researcher from Utrecht University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 19, co-authored 44 publications receiving 1748 citations. Previous affiliations of Jasper C A Broen include Radboud University Nijmegen.
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Journal ArticleDOI
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Timothy R D J Radstake,Olga Y. Gorlova,Blanca Rueda,Jose Ezequiel Martin,Behrooz Z. Alizadeh,Rogelio Palomino-Morales,Marieke J H Coenen,Madelon C. Vonk,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Jasper C A Broen,Piet L. C. M. van Riel,Ruben van 't Slot,Annet Italiaander,Roel A. Ophoff,Roel A. Ophoff,Gabriela Riemekasten,Nico Hunzelmann,Carmen P. Simeon,Norberto Ortego-Centeno,Miguel A. Gonzalez-Gay,María Francisca González-Escribano,Paolo Airò,Jaap M van Laar,Ariane L. Herrick,Jane Worthington,Roger Hesselstrand,Vanessa Smith,Filip De Keyser,Fredric Houssiau,Meng May Chee,Rajan Madhok,Paul G. Shiels,Rene Westhovens,Alexander Kreuter,Hans P. Kiener,Elfride De Baere,Torsten Witte,Leonid Padykov,Lars Klareskog,Lorenzo Beretta,Rafaella Scorza,Benedicte A. Lie,Anna Maria Hoffmann-Vold,Patricia Carreira,John Varga,Monique Hinchcliff,Peter K. Gregersen,Annette Lee,Jun Ying,Younghun Han,Shih-Feng Weng,Christopher I. Amos,Fredrick M. Wigley,Laura K. Hummers,J. Lee Nelson,Sandeep K. Agarwal,Shervin Assassi,Pravitt Gourh,Filemon K. Tan,Bobby P. C. Koeleman,Frank C. Arnett,Javier Martín,Maureen D. Mayes +63 more
TL;DR: The first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls identified a new susceptibility locus for systemic sclerosis at CD247 (1q22–23, rs2056626).
Journal ArticleDOI
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
Olga Y. Gorlova,Jose Ezequiel Martin,Blanca Rueda,Bobby P. C. Koeleman,Jun Ying,María Teruel,Lina-Marcela Diaz-Gallo,Jasper C A Broen,Madelon C. Vonk,Carmen P. Simeon,Behrooz Z. Alizadeh,Marieke J H Coenen,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Piet L. C. M. van Riel,Marie Vanthuyne,Ruben van 't Slot,Annet Italiaander,Roel A. Ophoff,Nicolas Hunzelmann,V. Fonollosa,Norberto Ortego-Centeno,Miguel A. Gonzalez-Gay,Francisco J. García-Hernández,María F. González-EscribanoMarí,Paolo Airò,Jacob M van Laar,Jane Worthington,Roger Hesselstrand,Vanessa Smith,Filip De Keyser,Fredric Houssiau,Meng May Chee,Rajan Madhok,Paul G. Shiels,Rene Westhovens,Alexander Kreuter,Elfride De Baere,Torsten Witte,Leonid Padyukov,Annika Nordin,Raffaella Scorza,Claudio Lunardi,Benedicte A. Lie,Anna Maria Hoffmann-Vold,Øyvind Palm,García P. de la Peña Paloma,Patricia Carreira,John Varga,Monique Hinchcliff,Annette Lee,Pravitt Gourh,Christopher I. Amos,F. M. Wigley,Laura K. Hummers,J. Hummers,J. Lee Nelson,G. Riemekasten,Ariane L. Herrick,Lorenzo Beretta,Carmen Fonseca,Christopher P. Denton,Peter K. Gregersen,Sandeep K. Agarwal,Shervin Assassi,Filemon K. Tan,Frank C. Arnett,Timothy R D J Radstake,Maureen D. Mayes,Javier Martín +69 more
TL;DR: The aim of this study was to determine the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc), and to identify three new non-HLA genes associated with SSc clinical and auto-antibody subgroups.
Journal ArticleDOI
Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder
Marco P. Boks,Hans C. van Mierlo,Bart P. F. Rutten,Timothy R D J Radstake,Lot de Witte,Elbert Geuze,Elbert Geuze,Steve Horvath,Leonard C. Schalkwyk,Christiaan H. Vinkers,Jasper C A Broen,Eric Vermetten,Eric Vermetten +12 more
TL;DR: Overall, in this longitudinal study of military personnel deployed to Afghanistan, an acceleration of ageing by trauma is shown, however, development of PTSD symptoms was associated with telomere lengthening and reversed epigenetic ageing.
Journal ArticleDOI
Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis
Maureen D. Mayes,Lara Bossini-Castillo,Olga Y. Gorlova,Jose Ezequiel Martin,Xiaodong Zhou,Wei V. Chen,Shervin Assassi,Jun Ying,Filemon K. Tan,Frank C. Arnett,John D. Reveille,Sandra G. Guerra,María Teruel,F.D. Carmona,Peter K. Gregersen,Annette Lee,Elena López-Isac,Eguzkine Ochoa,Patricia Carreira,Carmen P. Simeon,Ivan Castellví,Miguel A. González-Gay,Alexandra Zhernakova,Leonid Padyukov,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Cisca Wijmenga,Matthew A. Brown,Lorenzo Beretta,Gabriela Riemekasten,Torsten Witte,Nicolas Hunzelmann,Alexander Kreuter,Jörg H W Distler,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Roger Hesselstrand,Annika Nordin,Paolo Airò,Claudio Lunardi,Paul G. Shiels,Jacob M van Laar,Ariane L. Herrick,Jane Worthington,Christopher P. Denton,Fredrick M. Wigley,Laura K. Hummers,John Varga,Monique Hinchcliff,Murray Baron,Marie Hudson,Janet E. Pope,Daniel E. Furst,Dinesh Khanna,Kristin Phillips,Elena Schiopu,Barbara M. Segal,Jerry A. Molitor,Richard M. Silver,Virginia D. Steen,Robert W. Simms,Robert Lafyatis,Barri J. Fessler,Tracy M. Frech,Firas Alkassab,Peter Docherty,Elzbieta Kaminska,Nader Khalidi,Henry Niall Jones,Janet Markland,David Robinson,Jasper C A Broen,Jasper C A Broen,Timothy R D J Radstake,Timothy R D J Radstake,Carmen Fonseca,Bobby P. C. Koeleman,Javier Martín +77 more
TL;DR: This study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
Journal ArticleDOI
Mycophenolate mofetil, azathioprine and tacrolimus: mechanisms in rheumatology
TL;DR: A broad array of trials with mycophenolate mofetil, azathioprine and/or tacrolimus are ongoing within the field of rheumatology that might provide further novel avenues for the use of these drugs.