Michal Mokry

TL;DR: It is shown that innate lymphoid cells (ILCs), potent producers of interleukin-22 (IL-22) after intestinal injury, increase the growth of mouse small intestine organoids in an IL-22-dependent fashion, revealing a fundamental mechanism by which the immune system is able to support the intestinal epithelium, activating ISCs to promote regeneration.

TL;DR: This work determines genome-wide mutation patterns in ASCs of the small intestine, colon and liver of human donors with ages ranging from 3 to 87 years by sequencing clonal organoid cultures derived from primary multipotent cells.

TL;DR: The data show that location‐specific function is intrinsically programmed in the adult stem cells of the small intestine and that their differentiation fate is independent of location‐ specific extracellular signals, which implies that it is important to generate GATA4‐positive and Gata4‐negative cultures to regenerate all essential functions of thesmall intestine.

TL;DR: This detailed definition of cell communities at play in atherosclerosis will facilitate cell-based mapping of novel interventional targets with direct functional relevance for the treatment of human disease.

TL;DR: This work shows that Ascl2 is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and that Wnt/R-spondin can activate this regulatory loop.