S
Smita Srivastava
Researcher at Indian Institute of Technology Madras
Publications - 40
Citations - 1281
Smita Srivastava is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Azadirachtin & Hairy root culture. The author has an hindex of 15, co-authored 40 publications receiving 998 citations. Previous affiliations of Smita Srivastava include Indian Institute of Technology Delhi & Indian Institutes of Technology.
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Journal ArticleDOI
Hairy Root Culture for Mass-Production of High-Value Secondary Metabolites
TL;DR: The present review highlights the nature, applications, perspectives and scale up of hairy root cultures for the production of valuable secondary metabolites.
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Elicitation: a stimulation of stress in in vitro plant cell/tissue cultures for enhancement of secondary metabolite production
M. Narayani,Smita Srivastava +1 more
TL;DR: Integration of transcriptomics, proteomics and metabolomics with system biology can aid in discovery of novel genes, transcriptional factors and several biosynthetic pathways which in turn can serve as a valuable tool for metabolic engineering and gene manipulation for enhancing the yield and productivity of secondary metabolites.
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Endophytes as in vitro production platforms of high value plant secondary metabolites.
TL;DR: Various bioprocess optimization strategies that have been applied to sustain and enhance the product yield from the endophytes have been described in detail and techniques like mixed fermentation/co-cultivation and use of epigenetic modifiers have also been discussed as potential strategies to activate cryptic gene clusters in endophytic fungi, thereby aiding in novel metabolite discovery and overcoming the limitations associated with axenic culture.
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Enhanced camptothecin production by ethanol addition in the suspension culture of the endophyte, Fusarium solani
TL;DR: The study indicates a dual role of ethanol, presumably as an elicitor and also as a carbon/energy source, leading to enhanced biomass and camptothecin production.
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Effect of fermentation parameters, elicitors and precursors on camptothecin production from the endophyte Fusarium solani.
TL;DR: The cytotoxicity analysis of the crude camptothecin extract from the fungal biomass revealed its high effectiveness against colon and mammary gland cancer cell lines and provides immense scope for further enhancement in campthecin productivity at bioreactor level.