Journal ArticleDOI
Effect of fermentation parameters, elicitors and precursors on camptothecin production from the endophyte Fusarium solani.
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TLDR
The cytotoxicity analysis of the crude camptothecin extract from the fungal biomass revealed its high effectiveness against colon and mammary gland cancer cell lines and provides immense scope for further enhancement in campthecin productivity at bioreactor level.About:
This article is published in Bioresource Technology.The article was published on 2016-04-01. It has received 48 citations till now. The article focuses on the topics: Blood serum & Camptothecin.read more
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Metabolic engineering of yeast for fermentative production of flavonoids
Angelica Rodriguez,Tomas Strucko,Steen Gustav Stahlhut,Mette Kristensen,Daniel Killerup Svenssen,Jochen Förster,Jens Nielsen,Irina Borodina +7 more
TL;DR: Yeast Saccharomyces cerevisiae was engineered for de novo production of six different flavonoids directly from glucose, without supplementation of expensive intermediates, demonstrating the potential of flavonoid-producing yeast cell factories.
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Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites.
TL;DR: This review comprehensively highlights over the period 1981-2019, the bioactive potential of metabolites produced by endophytes from Fusarium genus to exhibit an incredible array of biological activities including antimicrobial, anticancer, antiviral, antioxidants, antiparasitics, immunosuppressants, immunomodulatory, antithrombotic, and biocontrol ability against plants pathogens and nematodes.
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Endophytic Bacteria Isolated from Panax ginseng Improves Ginsenoside Accumulation in Adventitious Ginseng Root Culture.
TL;DR: The combination of methyl jasmonate and strain LB 5-3 had a negative effect on ginseng adventitious root growth and ginsenoside production.
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Antiproliferative and Antioxidative Bioactive Compounds in Extracts of Marine-Derived Endophytic Fungus Talaromyces purpureogenus.
TL;DR: The ethyl acetate extract induced membrane damage and mitochondrial depolarization and thereby apoptosis and cytotoxicity in HeLa cells, marking marine-derived endophytes as potential sources for discovery of novel drugs.
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Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions.
Lu Yan,Haobin Zhao,Xixi Zhao,Xiaoguang Xu,Yichao Di,Chunmei Jiang,Junling Shi,Dongyan Shao,Qingsheng Huang,Hui Yang,Mingliang Jin +10 more
TL;DR: The biotechnological applications of endophytic fungi and their metabolites in agriculture, environment, biomedicine, energy, and biocatalysts are highlighted and bottlenecks in industrial development and commercial applications as well as possible solutions are discussed.
References
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Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
TL;DR: Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
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An endophytic fungus from Nothapodytes foetida that produces camptothecin.
TL;DR: Isolation of an organism producing camptothecin and its fermentation may, in the future, provide an easily accessible source for the production of this anticancer drug precursor molecule.
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An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues
TL;DR: The results offer a caution as to the possibility of using endophytic fungi as alternate sources of plant secondary metabolite production, and further studies have been initiated on the analysis of the upstream metabolic intermediates to understand the steps at which the production of the metabolites in question is constrained.
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Plant-derived bioactive compounds produced by endophytic fungi.
TL;DR: This review mainly deals with the research progress on endophytic fungi for producing plant-derived bioactive compounds such as paclitaxel, podophyllotoxin, camptothecine, vinblastine, hypericin, and diosgenin.
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Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin
S. Shweta,Sebastian Zuehlke,B. T. Ramesha,V. Priti,P. Mohana Kumar,Gudasalamani Ravikanth,Michael Spiteller,Ramesh Vasudeva,R. Uma Shaanker +8 more
TL;DR: Endophytic fungi strains from Apodytes dimidiata (Icacinaceae), a medium sized tree from the Western Ghats, India are isolated and identified as Fusarium solani using both ITS rDNA sequencing and spore morphology, both of which produced camptothecin and 9-methoxycamPTothecin in their mycelia.