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Smruti Pushalkar
Researcher at New York University
Publications - 35
Citations - 2388
Smruti Pushalkar is an academic researcher from New York University. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 15, co-authored 28 publications receiving 1491 citations. Previous affiliations of Smruti Pushalkar include University of York & Maharaja Sayajirao University of Baroda.
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Journal ArticleDOI
The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression
Smruti Pushalkar,Mautin Hundeyin,Donnele Daley,Constantinos P. Zambirinis,Emma Kurz,Ankita Mishra,Navyatha Mohan,Berk Aykut,Mykhaylo Usyk,Luisana E. Torres,Gregor Werba,Kevin Zhang,Yuqi Guo,Qianhao Li,Neha Akkad,Sarah Lall,Benjamin Wadowski,Johana Gutierrez,Juan A. Kochen Rossi,Jeremy Herzog,Brian Diskin,Alejandro Torres-Hernandez,Josh Leinwand,Wei Wang,Pardeep S. Taunk,Shivraj Savadkar,Malvin N. Janal,Anjana Saxena,Xin Li,Deirdre Jill Cohen,R. Balfour Sartor,R. Balfour Sartor,Deepak Saxena,George Miller,George Miller +34 more
TL;DR: It is found that a distinct and abundant microbiome drives suppressive monocytic cellular differentiation in pancreatic cancer via selective Toll-like receptor ligation leading to T-cell anergy, and that the microbiome has potential as a therapeutic target in the modulation of disease progression.
Journal ArticleDOI
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
Berk Aykut,Smruti Pushalkar,Ruonan Chen,Qianhao Li,Raquel Abengozar,Jacqueline I. Kim,Sorin A. A. Shadaloey,Dongling Wu,Pamela Preiss,Narendra Verma,Yuqi Guo,Anjana Saxena,Anjana Saxena,Mridula Vardhan,Brian Diskin,Wei Wang,Joshua Leinwand,Emma Kurz,Juan A. Kochen Rossi,Mautin Hundeyin,Constantinos Zambrinis,Xin Li,Deepak Saxena,George Miller +23 more
TL;DR: It is shown that fungi migrate from the gut lumen to the pancreas, and that this is implicated in the pathogenesis of pancreatic ductal adenocarcinoma (PDA), and that pathogenic fungi promote PDA by driving the complement cascade through the activation of MBL.
Journal ArticleDOI
Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma
Smruti Pushalkar,Xiaojie Ji,Yihong Li,Cherry L. Estilo,Ramanathan Yegnanarayana,Bhuvanesh Singh,Xin Li,Deepak Saxena +7 more
TL;DR: The underlying changes in the bacterial diversity in the oral mucosal tissues from non-tumor and tumor sites of OSCC subjects indicated a shift in bacterial colonization.
Journal ArticleDOI
Pancreatic cancer, inflammation, and microbiome.
TL;DR: The elucidation of the interplay between inflammation and microbiome in the context of pancreatic carcinogenesis will provide novel targets for intervention to prevent and treat pancreatic cancer more efficiently.
Journal ArticleDOI
Microbial diversity in saliva of oral squamous cell carcinoma
Smruti Pushalkar,Shrinivasrao P. Mane,Xiaojie Ji,Yihong Li,Clive Evans,Oswald Crasta,Douglas E. Morse,Robert J. Meagher,Anup K. Singh,Deepak Saxena +9 more
TL;DR: The species diversity estimates obtained with abundance-based coverage estimators and Chao1 were greater than published analyses of other microbial profiles from the oral cavity.