Showing papers by "So Young Kim published in 2004"
TL;DR: The results indicated that the antioxidantActivity of CP extracts was significantly affected by heating temperature and duration of treatment on CP and that the heating process can be used as a tool for increasing the antioxidant activity of CP.
Abstract: The effect of heat treatment on the antioxidant activity of extracts from Citrus unshiu peels was evaluated. Citrus peels (CP) (5 g) were placed in Pyrex Petri dishes (8.0 cm diameter) and heat-treated at 50, 100, or 150 °C for 10, 20, 30, 40, 50, and 60 min in an electric muffle furnace. After heat treatment, 70% ethanol extract (EE) and water extract (WE) (0.1 g/10 mL) of CP were prepared, and total phenol contents (TPC), radical scavenging activity (RSA), and reducing power of the extracts were determined. The antioxidant activities of CP extracts increased as heating temperature increased. For example, heat treatment of CP at 150 °C for 60 min increased the TPC, RSA, and reducing power of EE from 71.8 to 171.0 μM, from 29.64 to 64.25%, and from 0.45 to 0.82, respectively, compared to non-heat-treated control. In the case of WE from CP heat-treated at the same conditions (150 °C for 60 min), the TPC, RSA, and reducing power also increased from 84.4 to 204.9 μM, from 15.81 to 58.26%, and from 0.27 to 0....
511 citations
TL;DR: It is demonstrated that Myc stability is regulated at both the ubiquitylation and postubiquitylation levels, and revealed that substrates of the Ub – proteasome system can be targeted for destruction differently in different cell types.
Abstract: Myc is a highly unstable transcription factor that is destroyed by ubiquitin (Ub)-mediated proteolysis. We have previously identified an amino-terminal 'degron' within Myc that signals its destruction; this degron spans the transcriptional activation domain of Myc, and includes two highly conserved regions called Myc boxes I and II. We now report the identification of a second element--the D-element--which is also required for Myc proteolysis. The centrally located D-element is distinct from the PEST domain in Myc, but includes Myc box III, a third highly conserved region with no previously known function. We show that deletion of the D-element stabilizes the Myc protein without affecting its ubiquitylation, and report that the D-element and the degron act in a cell-type-specific manner to direct Myc proteolysis. These data thus demonstrate that Myc stability is regulated at both the ubiquitylation and postubiquitylation levels, and reveal that substrates of the Ub-proteasome system can be targeted for destruction differently in different cell types.
53 citations
TL;DR: An omission from the ‘Acknowledgement’ section is identified and the following sentence should have been inserted at the end of this section: ‘This work was supported by the Irving Hansen Memorial Foundation.
Abstract: Correction to: Oncogene (2004) 23, 3863–3871. doi:10.1038/sj.onc.1207492 Published online 8 December 2003 Since publication of the above manuscript, the authors have identified an omission from the ‘Acknowledgement’ section. The following sentence should have been inserted at the end of this section: ‘This work was supported by the Irving Hansen Memorial Foundation.
6 citations