Sofia Falzarano

TL;DR: This review will consider the ability of selective analogues (ligands able to discriminate between different biological responses) to activate a single spectrum of signal transduction pathways capable of producing a unique set of cellular responses, hypothesising that a distinctive imprint of signal protein activation may exist.

TL;DR: The obtained results confirm cell‐free splicing assay as an alternative system to test exon skipping propensity when patients' cells are unavailable and highlights the complexity of identifying optimal AONs for skipping exons with small mutations.

TL;DR: It is shown that PMMA/N-isopropil-acrylamide+ (NIPAM) nanoparticles (ZM2) bind and convey antisense oligoribonucleotides (AONs) very efficiently and this finding reveals arrector pili smooth muscle to be an appealing biomarker candidate and a novel low-invasive treatment end point.

TL;DR: It is demonstrated that N/OFQ stimulates human monocyte chemotaxis via NOP receptor activation through the order of potency of agonists and the antagonist selectivity.

TL;DR: The mitochondrial dysfunction induced by NaN3 provides a common platform for investigating the mechanisms of both ischemic and degenerative neuronal injury, useful for screening potential protective agents against neuronal death.