Journal ArticleDOI
Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation.
TLDR
It is demonstrated that N/OFQ stimulates human monocyte chemotaxis via NOP receptor activation through the order of potency of agonists and the antagonist selectivity.About:
This article is published in Peptides.The article was published on 2005-08-01. It has received 45 citations till now. The article focuses on the topics: Monocyte chemotaxis & Leukocyte chemotaxis.read more
Citations
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Journal ArticleDOI
The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential
TL;DR: The N/OFQ-NOP system has been implicated in a wide range of biological functions, including pain, drug abuse, cardiovascular control and immunity as mentioned in this paper, and the current status of the very limited number of clinical trials.
Journal ArticleDOI
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems
TL;DR: How NOP pharmacology intersects, contrasts, and interacts with the mu opioid receptor in terms of tertiary structure and mechanism of receptor activation; location of receptors in the central nervous system; mechanisms of desensitization and downregulation; cellular actions; intracellular signal transduction pathways; and behavioral actions with respect to analgesia, tolerance, dependence, and reward is discussed.
Journal ArticleDOI
Opioids and immune modulation: more questions than answers
TL;DR: It is suggested that further studies in the clinical setting are needed to accurately define the cellular target for immune modulation and suggest further investigation is required.
Journal ArticleDOI
Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression
TL;DR: A broad role for opioids in the modulation of the function of the immune system is suggested, and possible targets for the development of new therapeutics for inflammatory and infectious diseases are suggested.
Journal ArticleDOI
Endogenous opiates and behavior: 2005.
Richard J. Bodnar,Gad Klein +1 more
TL;DR: This paper is the 28th consecutive installment of the annual review of research concerning the endogenous opioid system, and summarizes papers published during 2005 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists.
References
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Journal ArticleDOI
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Jean-Claude Meunier,Catherine Mollereau,Lawrence Toll,Lawrence Toll,Charles Suaudeau,Christiane Moisand,Paul Alvinerie,Jean-Luc Butour,Jean-Claude Guillemot,Pascual Ferrara,Bernard Monsarrat,Honoré Mazarguil,Gilbert Vassart,Marc Parmentier,Jean Costentin +14 more
TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Journal ArticleDOI
Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.
Rainer K. Reinscheid,Hans Peter Nothacker,Anne Bourson,Ali Ardati,Robert Henningsen,James R. Bunzow,David K. Grandy,Hanno Langen,Frederick J. Monsma,Olivier Civelli +9 more
TL;DR: Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity.
Journal ArticleDOI
Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.
Sally H. Zigmond,James G. Hirsch +1 more
TL;DR: In both systems the results indicate that under certain conditions leukocytes, and in particular PMNs, release into the medium a factor stimulating locomotion and exerting chemotactic action on PMNs in the vicinity.
Journal ArticleDOI
ORL1, a novel member of the opioid receptor family: Cloning, functional expression and localization
Catherine Mollereau,Marc Parmentier,Pierre Mailleux,Jean-Luc Butour,Christiane Moisand,Pascale Chalon,Daniel Caput,Gilbert Vassart,Jean-Claude Meunier +8 more
TL;DR: It is concluded that the hORL1 receptor is a new member of the opioid receptor family with a potential role in modulating a number of brain functions, including instinctive behaviours and emotions.
Journal ArticleDOI
Formyl-peptide receptors revisited
TL;DR: This work has shown that the formyl-peptide receptor and its variant FPRL1 (FPR-like 1) are involved in host defense against bacterial infection and in the clearance of damaged cells, and suggests that these receptors contribute to disease pathogenesis and host defense.