Sofia Xanthoulea

TL;DR: Endothelium-restricted inhibition of NF-kappaB activation resulted in strongly reduced atherosclerotic plaque formation in ApoE(-/-) mice fed with a cholesterol-rich diet and inhibited proinflammatory gene expression at the arterial wall and promotes the pathogenesis of atherosclerosis.

TL;DR: This review describes the recent technological developments in NGS applied to the field of oncology and a number of clinical applications are reviewed, i.e., mutation detection in inherited cancer syndromes based on DNA- sequencing, detection of spliceogenic variants based on RNA-sequencing, DNA-sequenced to identify risk modifiers and application for pre-implantation genetic diagnosis, cancer somatic mutation analysis, pharmacogenetics and liquid biopsy.

TL;DR: It is shown that knock-in mice expressing a mutated nonsheddable p55TNFR develop Toll-like receptor–dependent innate immune hyperreactivity, which renders their immune system more efficient at controlling intracellular bacterial infections.

TL;DR: Results indicate that tmTNF preserves a subset of the beneficial activities of TNF while lacking detrimental effects, and support the hypothesis that selective targeting of soluble TNF may offer several advantages over complete blockade of T NF in the treatment of chronic inflammation and autoimmunity.

TL;DR: The data indicate that despite M2 macrophages exhibit an anti-inflammatory phenotype in-vitro, they do not improve wound closure in wild type mice while they delay healing in diabetic mice, and topical application of ex-vivo generated M2macrophages is not beneficial and contraindicated for cell therapy of skin wounds.