S
Sohye Kang
Researcher at Amgen
Publications - 28
Citations - 3145
Sohye Kang is an academic researcher from Amgen. The author has contributed to research in topics: Cell culture & P110α. The author has an hindex of 18, co-authored 28 publications receiving 2983 citations. Previous affiliations of Sohye Kang include Scripps Research Institute & San Diego State University.
Papers
More filters
Journal ArticleDOI
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
TL;DR: The inhibitor of TOR, rapamycin, strongly interferes with cellular transformation induced by the PI3-kinase mutants, suggesting that the TOR and its downstream targets are essential components of the transformation process.
Journal ArticleDOI
Oncogenic PI3K deregulates transcription and translation.
TL;DR: The recent discoveries of cancer-specific mutations in PIK3CA, the gene that encodes the catalytic subunit p110 α of PI3K, have heightened the interest in the oncogenic potential of this lipid kinase and have made p110α an ideal drug target.
Journal ArticleDOI
Cancer-specific mutations in PIK3CA are oncogenic in vivo.
TL;DR: The in vivo oncogenicity of PIK3CA mutants in an avian species strongly suggests a critical role for these mutated proteins in human malignancies.
Journal ArticleDOI
Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
TL;DR: The surprising oncogenic potential of the wild-type non-α isoforms of class I phosphoinositide 3-kinase may explain the dearth of cancer-specific mutations in these proteins, because these non-β, -γ, and -δ isoforms could contribute to theoncogenic phenotype of the cell by differential expression.
Journal ArticleDOI
Cancer-specific mutations in phosphatidylinositol 3-kinase.
TL;DR: The location of the mutations on a model structure of p110 alpha indicates several distinct mechanisms for the gain of function, and the mutated p110alpha proteins are promising cancer targets.