M
Marc-André Elsliger
Researcher at Scripps Research Institute
Publications - 106
Citations - 4010
Marc-André Elsliger is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Thermotoga maritima & Structural genomics. The author has an hindex of 24, co-authored 106 publications receiving 3704 citations. Previous affiliations of Marc-André Elsliger include San Diego Supercomputer Center & Stanford University.
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Journal ArticleDOI
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Damian C. Ekiert,Gira Bhabha,Marc-André Elsliger,Robert H. E. Friesen,Mandy Jongeneelen,Mark Throsby,Jaap Goudsmit,Ian A. Wilson +7 more
TL;DR: TheCR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza.
Journal ArticleDOI
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Scott A. Lesley,Peter Kuhn,Adam Godzik,Ashley M. Deacon,I.I. Mathews,Andreas Kreusch,Glen Spraggon,Heath E. Klock,Daniel McMullan,Tanya Shin,Juli Vincent,Alyssa Robb,Linda S. Brinen,M. Miller,Timothy M. McPhillips,Mark A. Miller,Daniel Scheibe,Jaume M. Canaves,Chittibabu Guda,Lukasz Jaroszewski,Thomas L. Selby,Marc-André Elsliger,John Wooley,Susan S. Taylor,Keith O. Hodgson,Ian A. Wilson,Peter G. Schultz,Raymond C. Stevens +27 more
TL;DR: The design and implementation of a high-throughput structural genomics pipeline and its application to the proteome of the thermophilic bacterium Thermotoga maritima is described and successfully cloned and attempted expression of 1,376 of the predicted 1,877 genes.
Journal ArticleDOI
Rare cancer-specific mutations in PIK3CA show gain of function
TL;DR: Fifteen rare cancer-derived mutants of PIK3CA, the gene coding for the catalytic subunit p110α of phosphatidylinositol 3-kinase, show a gain of function: they induce rapamycin-sensitive oncogenic transformation of chicken embryo fibroblasts, constitutively activate Akt and TOR-mediated signaling, and show enhanced lipid kinase activity.
Journal ArticleDOI
Cancer-specific mutations in phosphatidylinositol 3-kinase.
TL;DR: The location of the mutations on a model structure of p110 alpha indicates several distinct mechanisms for the gain of function, and the mutated p110alpha proteins are promising cancer targets.
Journal ArticleDOI
The JCSG high‐throughput structural biology pipeline
Marc-André Elsliger,Ashley M. Deacon,Adam Godzik,Adam Godzik,Scott A. Lesley,Scott A. Lesley,John Wooley,Kurt Wüthrich,Ian A. Wilson +8 more
TL;DR: The Joint Center for Structural Genomics high-throughput structural biology pipeline has delivered more than 1000 structures to the community over the past ten years and has made a significant contribution to the overall goal of the NIH Protein Structure Initiative (PSI) of expanding structural coverage of the protein universe.