Somasundar Ashok

TL;DR: The constraints of microbial 3-HP production and possible solutions are described, and the future prospects of biological 3-hydroxypropionic acid production are discussed.

TL;DR: On the feasibility of producing 3-HP from glucose through the malonyl-CoA pathway, the strain was further developed by deleting the sucAB gene, encoding α-ketoglutarate dehydrogenase complex in tricarboxylic acid (TCA) cycle, or blocking lactate and acetate production pathways, and evaluated for the production of3-HP.

TL;DR: The feasibility of obtaining two commercially valuable chemicals, 3-HP and 1,3-PDO, at a significant scale is demonstrated and the dhaT-deletion mutant was attributed to the expression of NAD(P)H-dependent hypothetical oxidoreductase.

TL;DR: The results show that K. pneumoniae is potentially useful for the production of 3‐HP in an economical culture medium that does not require vitamin B12, and suggests that the aeration conditions should be optimized carefully for the efficient production of3‐HP while using this strain.

TL;DR: The potential use of nitrate as an electron acceptor both to regenerate NAD(+) and to prevent the formation of byproducts during anaerobic production of 3-HP from glycerol is investigated.