This review illustrates the need to use nuclear magnetic resonance (NMR) spectroscopy for the quantitative analysis of small molecules in their crude forms and in mixtures We provide the basic concepts of quantitative NMR (qNMR), a brief description of important acquisition and processing parameters responsible for obtaining high-quality, reproducible NMR spectra in order to maximize accuracy, and the latest referencing techniques used for quantitative analysis We also describe methods that are used for quantitative analysis including calibration-curve and standard-addition methods Further, we briefly address validation of qNMR spectroscopy and its major applications in various scientific disciplines

Quantitative 1H NMR spectroscopy

https://www.pcr.ugent.be/Publications/artikelsPCR/Progress%20in%20polymer%20science/TalhaGokmen2011.pdf

Porous Polymer Particles - A Comprehensive Guide to Synthesis, Characterization, Functionalization and Applications

NMR spectroscopy in environmental research: From molecular interactions to global processes

Sulfuric acid immobilized on silica: an excellent catalyst for Fischer type glycosylation ☆

http://su.diva-portal.org/smash/get/diva2:660872/FULLTEXT01

Complete 1H and 13C NMR chemical shift assignments of mono-, di-, and trisaccharides as basis for NMR chemical shift predictions of polysaccharides using the computer program casper

NIS/H2SO4-Silica: a mild and efficient reagent system for the hydrolysis of thioglycosides.

Lanthanum Trifluoromethane-sulfonate‐Catalyzed Facile Synthesis of Per‐O‐acetylated Sugars and Their One‐Pot Conversion to S‐Aryl and O‐Alkyl/Aryl Glycosides†

A novel application of in situ (1)H high-resolution magic angle spinning (HR-MAS) NMR technique for real-time monitoring of H(2)SO(4)-silica promoted formation of 2, 2-disubstituted quinozolin-4(3H)-ones is reported. The detailed NMR spectroscopic data led to elucidation of the mechanism, reaction optimization, kinetics and quantitative analysis of the product accurately and efficiently. The translation of the optimized parameters obtained by (1)H HR-MAS NMR in the wet laboratory provided similar results. It is proposed that (1)H HR-MAS has a potential utility for optimization of various organic transformations in solid supported catalyzed reactions.

Real time HR-MAS NMR: application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry.

Somnath Dasgupta

Papers

NIS/H2SO4-Silica: a mild and efficient reagent system for the hydrolysis of thioglycosides.

Lanthanum Trifluoromethane-sulfonate‐Catalyzed Facile Synthesis of Per‐O‐acetylated Sugars and Their One‐Pot Conversion to S‐Aryl and O‐Alkyl/Aryl Glycosides†

Real time HR-MAS NMR: application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry.

Synthesis of a core disaccharide from the Streptococcus pneumoniae type 23F capsular polysaccharide antigen.