S
Sonali Sengupta
Researcher at VIT University
Publications - 17
Citations - 353
Sonali Sengupta is an academic researcher from VIT University. The author has contributed to research in topics: Gene & HSF1. The author has an hindex of 9, co-authored 17 publications receiving 308 citations. Previous affiliations of Sonali Sengupta include Indian Institute of Technology Kanpur & Banaras Hindu University.
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Journal ArticleDOI
The malin–laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin–proteasome system
Punitee Garyali,Pratibha Siwach,Pankaj Kumar Singh,Rajat Puri,Shucchi Mittal,Sonali Sengupta,Rashmi Parihar,Subramaniam Ganesh +7 more
TL;DR: The results suggest that the malin-laforin complex is a novel player in the neuronal response to misfolded proteins and could be potential therapeutic targets for neurodegenerative disorders associated with cytotoxic proteins.
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Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression.
Anshika Goenka,Sonali Sengupta,Rajesh Pandey,Rashmi Parihar,Girish C. Mohanta,Mitali Mukerji,Subramaniam Ganesh +6 more
TL;DR: It is demonstrated here that the recruitment of CREBBP and SRSF1 to nSBs is Sat3-dependent, and that loss of Sat3 transcripts relieves the heat-shock-induced transcriptional repression of a few target genes.
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Malin and laforin are essential components of a protein complex that protects cells from thermal stress.
TL;DR: It is demonstrated that laforin and malin are key regulators of HSF 1 and that defects in the HSF1-mediated stress response pathway might underlie some of the pathological symptoms in LD.
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Altered Expression of the Noncoding hsrω Gene Enhances poly-Q Induced Neurotoxicity in Drosophila
TL;DR: It is shown that P insertion alleles of the hsrω gene, which cause its overexpression, dominantly enhance neurodegeneration in fly eyes expressing either expanded poly-Q (127Q) or mutant huntingtin protein.
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Satellite III non-coding RNAs show distinct and stress-specific patterns of induction
TL;DR: It is demonstrated here that the nSBs are induced by a variety of stressors and show stress-specific patterns of induction and suggest the existence of multiple transcriptional loci for the SatIII transcripts and that their activation might depend upon the type of stressor.