Showing papers by "Soo Hyun Lee published in 2021"

Web-above-a-Ring (WAR) and Web-above-a-Lens (WAL): Nanostructures for Highly Engineered Plasmonic-Field Tuning and SERS Enhancement

Abstract: Synthetic strategies of web-above-a-ring (WAR) and web-above-a-lens (WAL) nanostructures are reported. The WAR has a controllable gap between the nanoring core and a nanoweb with nanopores for the effective confinement of electromagnetic field in the nanogap and subsequent surface-enhanced Raman scattering (SERS) of Raman dyes inside the gap with high signal reproducibility, which are attributed to the generation of circular 3D hot zones along the rim of Pt@Au nanorings with wrapping nanoweb architecture. More specifically, Pt@Au nanorings are adopted as a plasmonic core for structural rigidity and built porous nanowebs above them through a controlled combination of galvanic exchange and the Kirkendall effect. Both nanoweb and nanolens structures are also formed on Pt@Au nanoring, which is WAL. structure. Remarkably, plasmonic hot zone, nanopores, and hot lens are formed inside a single WAL nanostructure, and these structural components are orchestrated to generate stronger SERS signals.

Au Nanorings with Intertwined Triple Rings.

Abstract: We designed complex Au nanorings with intertwined triple rings (ANITs) in a single entity to amplify the efficacy of near-field focusing. Such a complex and unprecedented morphology at the nanoscale was realized through on-demand multistepwise reactions. Triangular nanoprisms were first sculpted into circular nanorings, followed by a series of chemical etching and deposition reactions eventually leading to ANITs wherein thin metal bridges hold the structure together without any linker molecules. In the multistepwise reaction, the well-faceted growth pattern of Au, which induces the growth of two distinctive flat facets in a lateral direction, is important to evolve the morphology from single to multiple nanorings. Although our synthesis proceeds through multiple steps in one batch without purification steps, it shows a remarkably high yield (>∼90%) at the final stage. The obtained high degree of homogeneity (in both shape and size) of the resulting ANITs allowed us to systematically investigate the corresponding localized surface plasmon resonance (LSPR) coupling with varying nanoring arrangements and observe their single-particle surface enhanced Raman scattering (SERS). Surprisingly, individual ANITs exhibited an enormously large enhancement factor (∼109), which confirms their superior near-field focusing relative to other reported nanoparticles.

Au nanolenses for near-field focusing.

Abstract: We report a novel strategy for the synthesis of Pt@Au nanorings possessing near-field focusing capabilities at the center through which single-particle surface enhanced Raman scattering could be readily observed. We utilized Pt@Au nanorings as a light-absorber; the absorbed light could be focused at the center with the aid of a Au nanoporous structure. We synthesized the Au nanolens structure through a Galvanic exchange process between Au ions and Ag block at the inner domain of the Pt@Au nanoring. For this step, Ag was selectively pre-deposited at the inner domain of the Pt@Au nanorings through electrochemical potential-tuned growth control and different surface energies with regard to the inner and outer boundaries of the nanoring. Then, the central nanoporous architecture was fabricated through the Galvanic exchange of sacrificial Ag with Au ions leading to the resulting Au nanoring with a Au nanoporous structure at the center. We monitored the shape-transformation by observing their corresponding localized surface plasmon resonance (LSPR) profiles. By varying the rim thickness of the starting Pt@Au nanorings, the inner diameter of the nanolens was accordingly tuned to maximize near-field focusing, which enabled us to obtain the reproducible and light-polarization independent measurements of single-particle SERS. Through theoretical simulation, the near-field electromagnetic field focusing capability was visualized and confirmed through single-particle SERS measurement showing an enhancement factor of 1.9 × 108 to 1.0 × 109.

Weight-based vancomycin loading strategy may not improve achievement of optimal vancomycin concentration in patients with preserved renal function.

Abstract: We performed a retrospective study to evaluate clinical effectiveness of vancomycin loading strategy and factors associated with achieving optimal Cmin. Patients administered vancomycin for ≥72 h from January to June 2018 were enrolled. Patients were divided into two groups: loading (LD) and non-loading (NLD). LD was defined as initial vancomycin dose ≥20 mg/kg and ≥120% of maintenance dose. During study period, 70 and 71 received initial LD (24.2 ± 2.5 mg/kg) and NLD (17.3 ± 3.3 mg/kg) doses of vancomycin, respectively (p < .001). Achievement of optimal Cmin was not different before administration of the third dose (24.4% in LD versus 18.2% in NLD, p = .484) and within 72 h (22.9% versus 28.2%, p = .759). Risk factors for failure to achieve optimal Cmin before administration of the third dose were higher creatinine clearance and higher level of serum albumin. Therefore, more sufficient loading or patient-specific dose strategies should be used to achieve optimal serum vancomycin Cmin.