Sophie Dekoninck

TL;DR: In postnatal unperturbed mammary gland, both luminal and myoepithelial lineages contain long-lived unipotent stem cells that display extensive renewing capacities, as demonstrated by their ability to clonally expand during morphogenesis and adult life as well as undergo massive expansion during several cycles of pregnancy.

TL;DR: Quantitative analysis of clonal fate data and proliferation dynamics demonstrate the existence of two distinct proliferative cell compartments arranged in a hierarchy involving slow-cycling stem cells and committed progenitor cells in the skin interfollicular epidermis.

TL;DR: A dual role is identified for tumour-cell-derived V EGF in promoting cancer stemness: by stimulating angiogenesis in a paracrine manner, VEGF creates a perivascular niche for CSCs, and by directly affecting CSC’s through Nrp1 in an autocrine loop, VegF stimulatescancer stemness and renewal.

TL;DR: The cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis are shown and, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitor that expand and repair the wound.

TL;DR: The characteristics of skin epithelial stem cells, their heterogeneity, clonal dynamics, crosstalk with other cells and remarkable plasticity during wound healing are described.