Souichi Nakashima

TL;DR: The methanolic extract from the whole plants of Anastatica hierochuntica, an Egyptian herbal medicine, was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells and the inhibition of tyrosinase activity suggested to be important.

TL;DR: The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

TL;DR: From the methanolic extracts, a new alkaloid, N-methylasimilobine N-oxide, was isolated together with eleven benzylisoquinoline alkaloids, and its absolute stereostructure was determined from chemical and physicochemical evidence.

TL;DR: Most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti-proliferative activities.

TL;DR: It is suggested that the inhibition of coFilin's phosphorylation increased the severing activity of cofilin, and then the depolymerization of actin was enhanced after treatment with cucurbitacin E at lower concentrations.