Soyeon Shin

TL;DR: It is demonstrated that autophagy contributes to the cytotoxicity of DHA in cancer cells harboring wild-type p53, and compelling evidence for the interplay betweenAutophagy and apoptosis induced by DHA is supported by the findings that Autophagy inhibition suppressed apoptosis and further autophagic induction enhanced apoptosis in response to DHA treatment.

TL;DR: Results show that, in addition to apoptosis, DHA increased the expression levels of lipidated form LC3B and potently stimulated the autophagic flux, suggesting that DHA induces both autophagy and apoptosis in cancer cells expressing mutant p53.

TL;DR: In this article, the relationship between ω3-PUFAs and β-catenin, one of the key determinants of anticancer properties, was investigated. But the relationship was not shown to be causal.

TL;DR: Data suggest that DHA-induced apoptosis and autophagy in NSCLC cells are associated with AMPK activation and PI3K/Akt inhibition, which in turn lead to suppression of mTOR; thus ω3-PUFAs may be utilized as potential therapeutic agents for NSCLc treatment.

TL;DR: Results indicate that ω3-PUFAs induce cell death through apoptosis and autophagy in GBM cells; thus, it may be possible to use omega-3- PUFAs as chemopreventive and therapeutic agents for GBM.