S
Spyros Artavanis-Tsakonas
Researcher at Harvard University
Publications - 150
Citations - 34055
Spyros Artavanis-Tsakonas is an academic researcher from Harvard University. The author has contributed to research in topics: Notch signaling pathway & Notch proteins. The author has an hindex of 83, co-authored 150 publications receiving 32354 citations. Previous affiliations of Spyros Artavanis-Tsakonas include University of Geneva & Centre national de la recherche scientifique.
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Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
Journal Article
Notch signaling : Signal transduction
TL;DR: The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans and putative components of the signaling cascade are identified, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain.
Journal ArticleDOI
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin,Lily Ting,Raphael J. Bruckner,Fana Gebreab,Melanie P. Gygi,John Szpyt,Stanley Tam,Gabriela Zarraga,Greg Colby,Kurt Baltier,Rui Dong,Virginia Guarani,Laura Pontano Vaites,Alban Ordureau,Ramin Rad,Brian K. Erickson,Martin Wühr,Joel M. Chick,Bo Zhai,Deepak Kolippakkam,Julian Mintseris,Robert A. Obar,Robert A. Obar,Tim Harris,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas,Mathew E. Sowa,Pietro De Camilli,Joao A. Paulo,J. Wade Harper,Steven P. Gygi +30 more
TL;DR: Using high-throughput affinity-purification mass spectrometry, BioPlex is used to identify interacting partners for 2,594 human proteins in HEK293T cells and reveals associations among thousands of protein domains, suggesting a basis for examining structurally related proteins.
Journal ArticleDOI
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin,Raphael J. Bruckner,Joao A. Paulo,Joe R. Cannon,Lily Ting,Kurt Baltier,Greg Colby,Fana Gebreab,Melanie P. Gygi,Hannah Parzen,John Szpyt,Stanley Tam,Gabriela Zarraga,Laura Pontano-Vaites,Sharan Swarup,Anne E. White,Devin K. Schweppe,Ramin Rad,Brian K. Erickson,Robert A. Obar,Robert A. Obar,K. G. Guruharsha,Kejie Li,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas,Steven P. Gygi,J. Wade Harper +26 more
TL;DR: With more than 56,000 candidate interactions, BioPlex 2.0 exceeds previous experimentally derived interaction networks in depth and breadth, and will be a valuable resource for exploring the biology of incompletely characterized proteins and for elucidating larger-scale patterns of proteome organization.
Journal ArticleDOI
Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats
TL;DR: It is speculated that the Notch locus may be involved in a cell-cell interaction mechanism that is essential for the differentiation of the ectoderm into neural and epidermal precursors.