K
K. G. Guruharsha
Researcher at Biogen Idec
Publications - 10
Citations - 2500
K. G. Guruharsha is an academic researcher from Biogen Idec. The author has contributed to research in topics: Notch signaling pathway & Drosophila Protein. The author has an hindex of 7, co-authored 10 publications receiving 2101 citations. Previous affiliations of K. G. Guruharsha include University of Mysore & Harvard University.
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Journal ArticleDOI
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin,Raphael J. Bruckner,Joao A. Paulo,Joe R. Cannon,Lily Ting,Kurt Baltier,Greg Colby,Fana Gebreab,Melanie P. Gygi,Hannah Parzen,John Szpyt,Stanley Tam,Gabriela Zarraga,Laura Pontano-Vaites,Sharan Swarup,Anne E. White,Devin K. Schweppe,Ramin Rad,Brian K. Erickson,Robert A. Obar,Robert A. Obar,K. G. Guruharsha,Kejie Li,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas,Steven P. Gygi,J. Wade Harper +26 more
TL;DR: With more than 56,000 candidate interactions, BioPlex 2.0 exceeds previous experimentally derived interaction networks in depth and breadth, and will be a valuable resource for exploring the biology of incompletely characterized proteins and for elucidating larger-scale patterns of proteome organization.
Journal ArticleDOI
The Notch signalling system: recent insights into the complexity of a conserved pathway.
TL;DR: This work has revealed an extraordinarily complex network of genes that can affect Notch activity in Drosophila melanogaster and presented an unprecedented insight into the way in which such a fundamental signalling mechanism is controlled by the genome.
Journal ArticleDOI
A Protein Complex Network of Drosophila melanogaster
K. G. Guruharsha,Jean François Rual,Bo Zhai,Julian Mintseris,Pujita Vaidya,Namita Vaidya,Chapman N. Beekman,Christina Wong,David Y. Rhee,Odise Cenaj,Emily McKillip,Saumini Shah,Mark Stapleton,Kenneth H. Wan,Charles Yu,Bayan Parsa,Joseph W. Carlson,Xiao Chen,Bhaveen Kapadia,K. VijayRaghavan,Steven P. Gygi,Susan E. Celniker,Robert A. Obar,Spyros Artavanis-Tsakonas +23 more
TL;DR: The Drosophila protein interaction map (DPiM) represents the largest metazoan protein complex map and provides a valuable resource for analysis of protein complex evolution.
Journal ArticleDOI
Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy
Anindya Sen,Douglas N. Dimlich,K. G. Guruharsha,Mark W. Kankel,Kazuya Hori,Takakazu Yokokura,Sophie Brachat,Delwood Richardson,Joseph Loureiro,Rajeev Sivasankaran,Daniel Curtis,Lance S. Davidow,Lee L. Rubin,Anne C. Hart,David Van Vactor,Spyros Artavanis-Tsakonas +15 more
TL;DR: A unique interactome for SMN is defined that provides a knowledge base for a better understanding of SMA and more than 300 candidate genes that alter an Smn-dependent phenotype in vivo are identified.
Journal ArticleDOI
Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila
Marcus H. Stoiber,Marcus H. Stoiber,Sara Olson,Gemma E. May,Michael O. Duff,Jan Manent,Robert A. Obar,K. G. Guruharsha,K. G. Guruharsha,Peter J. Bickel,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas,James B. Brown,James B. Brown,Brenton R. Graveley,Susan E. Celniker +15 more
TL;DR: From the simultaneous acquisition and integrative analysis of protein and RNA constituents of RNPs, extensive cross-regulatory and hierarchical interactions in post-transcriptional control are identified.