Sreemathi Logan

TL;DR: 5XFAD mice rapidly recapitulate major features of AD amyloid pathology and may be useful models of intraneuronal Aβ42-induced neurodegeneration and amyloids plaque formation.

TL;DR: It is concluded that BACE1 elevation is most likely triggered by the amyloid pathway and may drive a positive-feedback loop in AD.

TL;DR: Astrocytic ablation of SOD2 impairs hippocampal-dependent plasticity in spatial working memory, reduces long-term potentiation of hippocampal neurons and levels of the neuromodulator d-serine, and increases astrogliosis, consistent with defects in advanced aging and Alzheimer's disease.

TL;DR: In this paper , a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) was used to generate a highly genetically diverse rat model from commercially available inbred rats.

TL;DR: For example, the authors found that 17α-E2 treatment significantly improved metabolic parameters and slowed aging in male mice without inducing significant feminization in both male and female mice, but this was partially blocked in female, but not male, ERβKO mice.