B
Brian Hitt
Researcher at Northwestern University
Publications - 7
Citations - 973
Brian Hitt is an academic researcher from Northwestern University. The author has contributed to research in topics: Biology & Tau protein. The author has an hindex of 4, co-authored 4 publications receiving 875 citations.
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Journal ArticleDOI
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
Tracy O'Connor,Katherine R. Sadleir,Erika Maus,Rodney A. Velliquette,Jie Zhao,Sarah L. Cole,William A. Eimer,Brian Hitt,Leslie A. Bembinster,Sven Lammich,Stefan F. Lichtenthaler,Sébastien S. Hébert,Bart De Strooper,Christian Haass,David A. Bennett,Robert Vassar +15 more
TL;DR: It is strongly suggested that eIF2alpha phosphorylation increases BACE1 levels and causes Abeta overproduction, which could be an early, initiating molecular mechanism in sporadic AD.
Journal ArticleDOI
β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis
Jie Zhao,Yifan Fu,Marina V. Yasvoina,Peizhen Shao,Brian Hitt,Tracy O'Connor,Sreemathi Logan,Erika Maus,Martin Citron,Robert W. Berry,Lester I. Binder,Robert Vassar +11 more
TL;DR: It is concluded that BACE1 elevation is most likely triggered by the amyloid pathway and may drive a positive-feedback loop in AD.
Journal ArticleDOI
β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects *♦
Brian Hitt,Sean M. Riordan,Lokesh Kukreja,William A. Eimer,Tharinda W. Rajapaksha,Robert Vassar +5 more
TL;DR: The results imply the possibility that axon mis-targeting may occur in adult neurogenic and/or regenerating neurons as a result of chronic Bace1 inhibition and add a note of caution to BACE1 inhibitor development.
Journal ArticleDOI
BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
TL;DR: The data indicate that BACE1 deficiency predisposes mice to spontaneous and pharmacologically-induced seizure activity, which has implications for the development of safe therapeutic strategies for reducing Aβ levels in Alzheimer's disease.
Posted ContentDOI
Tau seeding without tauopathy
Michael LaCroix,Brian Hitt,Joshua D. Beaver,Sandi J. Estill-Terpack,Kelly Gleason,Carol A. Tamminga,Bret M. Evers,Charles L. White,Marc I. Diamond +8 more
TL;DR: Tau’s ability to adopt self-replicating conformations under non-pathogenic conditions may reflect normal function that goes awry in disease states.