S
Sridevi Devaraj
Researcher at Baylor College of Medicine
Publications - 390
Citations - 23771
Sridevi Devaraj is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Metabolic syndrome & Proinflammatory cytokine. The author has an hindex of 85, co-authored 365 publications receiving 21831 citations. Previous affiliations of Sridevi Devaraj include University of Madras & Boston Children's Hospital.
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Journal ArticleDOI
Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome
Sridevi Devaraj,Simona Valleggi,Simona Valleggi,David Siegel,Ishwarlal Jialal,Ishwarlal Jialal +5 more
TL;DR: The role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes is outlined.
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Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications.
TL;DR: There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFκB activity, and TLR4 expression in T1DM, and future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population.
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Modern American scurvy - experience with vitamin C deficiency at a large children's hospital.
TL;DR: Vitamin C deficiency is not uncommon in large pediatric health care facilities, and it is frequently missed on clinical evaluation and diagnostic imaging, so scurvy should be considered and a serum ascorbic acid level checked to potentially confirm a diagnosis prior to further invasive tests.
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The biological effects of CRP are not attributable to endotoxin contamination: Evidence from TLR4 knockdown human aortic endothelial cells
TL;DR: This is the first study to positively authenticate the significance of earlier in vitro reports on CRP biological effects and demonstrate and confirm that the biological effects of CRP on HAECs are independent of LPS and thus are attributable to native protein per se.
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C-Reactive Protein Induces Release of Both Endothelial Microparticles and Circulating Endothelial Cells In Vitro and In Vivo: Further Evidence of Endothelial Dysfunction
TL;DR: Novel data is provided that CRP, via NO deficiency, promotes endothelial dysfunction by inducing release of CECs and EMPs, which are biomarkers of endothelium dysfunction.