S
Sridhar Hannenhalli
Researcher at University of Maryland, College Park
Publications - 184
Citations - 23355
Sridhar Hannenhalli is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 49, co-authored 162 publications receiving 21959 citations. Previous affiliations of Sridhar Hannenhalli include National Institutes of Health & University of Cambridge.
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Functional divergence of gene duplicates – a domain-centric view
TL;DR: The results suggest that the previously observed asymmetry in the overall duplicate protein evolution is largely due to divergence of specific domains of the protein, and coincides with divergence in spatial expression domains.
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Dense subgraph computation via stochastic search
TL;DR: A generic stochastic search based method to compute dense subgraphs in a graph with an arbitrary number of partitions and an arbitrary connectivity among the partitions is reported and used to explore tissue-specific transcriptional regulation in the human genome.
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Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature
Jian Li,Nina M. Bowens,Lan Cheng,Xiaohong Zhu,Mary Chen,Sridhar Hannenhalli,Thomas P. Cappola,Michael S. Parmacek +7 more
TL;DR: Data demonstrate that MKL2 regulates a conserved TGF-β signaling pathway that is required for angiogenesis and ultimately embryonic survival.
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Epigenomic and RNA structural correlates of polyadenylation.
TL;DR: A causative link between chromatin structure and mRNA structure is suggested whereby a compacted chromatin downstream of the poly(A) site slows down the elongating transcript, thus facilitating the folding of nascent mRNA in a favorable structure at poly( a) site during transcription.
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Positional sequencing by hybridization
TL;DR: In this paper, it was shown that the positional eulerian path problem is NP-complete even when the maximum out-degree (in-degree) of any vertex in the graph is 2.