S
Sridhar Hannenhalli
Researcher at University of Maryland, College Park
Publications - 184
Citations - 23355
Sridhar Hannenhalli is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 49, co-authored 162 publications receiving 21959 citations. Previous affiliations of Sridhar Hannenhalli include National Institutes of Health & University of Cambridge.
Papers
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Journal ArticleDOI
Putative functional genes in idiopathic dilated cardiomyopathy.
Nishanth Ulhas Nair,Avinash Das,Uri Amit,Welles Robinson,Seung Gu Park,Mahashweta Basu,Alex Lugo,Jonathan Leor,Jonathan Leor,Eytan Ruppin,Eytan Ruppin,Sridhar Hannenhalli +11 more
TL;DR: The stratification of DCM patients based on cardiac expression of the functional genes reveals two subgroups differing in key cardiac phenotypes, and a list of investigational drugs that target the newly identified functional genes that may lead to cardiac side effects is provided.
Book ChapterDOI
An interaction-dependent model for transcription factor binding
TL;DR: This work believes that modeling this interaction-dependent binding with linear regression can better explain the observed binding data and assesses this hypothesis based on the whole genome ChIP-on-chip data for Yeast.
Journal ArticleDOI
Correlated changes between regulatory cis elements and condition-specific expression in paralogous gene families
TL;DR: The relationship between cis element divergence and condition-specific expression divergence among paralogous genes in Saccharomyces cerevisiae is characterized and it is suggested that GAL4 binding plays a major role in the expression divergence of the genes in the sugar transporter family.
Posted ContentDOI
Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival
Nishanth Ulhas Nair,Avinash Das,Vasiliki-Maria Rogkoti,Michiel Fokkelman,Richard Marcotte,Chiaro G. de Jong,Joo Sang Lee,Isaac Meilijson,Sridhar Hannenhalli,Benjamin G. Neel,Bob van de Water,Sylvia E. Le Dévédec,Eytan Ruppin +12 more
TL;DR: It is shown that cytoskeletal drugs might be more beneficial in patients with high predicted migration levels, and the importance of migration levels in determining patient survival is testified to.
Journal ArticleDOI
Immune cell gene expression signatures in diffuse glioma are associated with IDH mutation status, patient outcome and malignant cell state, and highlight the importance of specific cell subsets in glioma biology
Bharati Mehani,Saleembhasha Asanigari,Hye-Jung Chung,Karen Dazelle,Ajay K. Singh,Sridhar Hannenhalli,Kenneth Aldape +6 more
TL;DR: In this paper , the authors found that the proportions and estimated gene expression patterns of specific immune cells significantly varied according to IDH mutation status and showed a significant association of monocytic lineage cell gene expression clusters with patient survival and with mesenchymal gene expression scores.