Sridhar Hannenhalli

TL;DR: Algorithms to analyze rearrangements of multiple genomes were developed and applied to the derivation of most parsimonious scenarios of herpesvirus evolution under different evolutionary models, which will be applicable to the comparative analysis of bacterial and eukaryotic genomes as soon as their sequences become available.

TL;DR: Recent attempts to improve computational identification of transcription factor binding sites through two types of approaches are discussed: approaches that aim to improve binding motif models by extracting maximal sequence information from experimentally determined binding sites and approaches that supplementbinding motif models with additional genomic or other attributes (such as evolutionary conservation).

TL;DR: Maternal pronuclear transfer and C TCF mRNA microinjection experiments indicate that CTCF is a mammalian maternal effect gene, and that persistent transcriptional defects rather than persistent chromosomal defects perturb early embryonic development.

TL;DR: Although the analysis did not find evidence for a global coordinated program of fetal gene expression in adult myocardial adaptation, the analysis revealed specific gene expression modules active during both development and disease and specific candidates for their regulation.

TL;DR: It is shown that cSLi can successfully predict patients’ drug treatment response and provide patient stratification signatures, and complements existing actionable mutation-based methods for precision cancer therapy, offering an opportunity to expand its scope to the whole genome.