M
Michael S. Parmacek
Researcher at University of Pennsylvania
Publications - 89
Citations - 8168
Michael S. Parmacek is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cellular differentiation & Vascular smooth muscle. The author has an hindex of 47, co-authored 87 publications receiving 7688 citations. Previous affiliations of Michael S. Parmacek include University of Michigan & Cardiovascular Institute of the South.
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Journal ArticleDOI
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
Chay T. Kuo,Edward E. Morrisey,Roshani T. Anandappa,Kirsten Sigrist,Min M. Lu,Michael S. Parmacek,Claire Soudais,Jeffrey M. Leiden +7 more
TL;DR: Analysis of cardiac development in the GATA4-/- mice demonstrated that these embryos developed splanchnic mesoderm, which differentiated into primitive cardiac myocytes that expressed contractile proteins that formed aberrant cardiac structures in the anterior and dorsolateral regions of the embryo.
Journal ArticleDOI
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
Edward E. Morrisey,Zhihua Tang,Kirsten Sigrist,Min Min Lu,Fang Jiang,Hon S. Ip,Michael S. Parmacek +6 more
TL;DR: A model in which GATA6 lies upstream of HNF4 in a transcriptional cascade that regulates differentiation of the visceral endoderm is suggested and it is demonstrated that GATA 6 is required for establishment of the endODermally derived bronchial epithelium.
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Myocardin Is a Critical Serum Response Factor Cofactor in the Transcriptional Program Regulating Smooth Muscle Cell Differentiation
Kevin L. Du,Hon S. Ip,Jian Li,Mary Chen,Frédéric Dandré,William W. Yu,Min Min Lu,Gary K. Owens,Michael S. Parmacek +8 more
TL;DR: Data demonstrate that myocardin plays an important role in the SRF-dependent transcriptional program that regulates SMC development and differentiation.
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A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
Yuzhen Zhang,Ashley M. Goss,Ethan D. Cohen,Rachel S. Kadzik,John J. Lepore,Karthika Muthukumaraswamy,Jifu Yang,Francesco J. DeMayo,Jeffrey A. Whitsett,Michael S. Parmacek,Edward E. Morrisey +10 more
TL;DR: It is demonstrated that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration.
Journal ArticleDOI
Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.
TL;DR: The molecular basis of MRTF function is reviewed with particular focus on the role MRTFs play in regulating cardiovascular patterning, vascular smooth muscle cell and cardiomyocyte differentiation and in the pathogenesis of congenital heart disease and vascular proliferative syndromes.