S
Srihari Konduri
Researcher at Vignan University
Publications - 13
Citations - 191
Srihari Konduri is an academic researcher from Vignan University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 8 publications receiving 77 citations. Previous affiliations of Srihari Konduri include University of Montana.
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Journal ArticleDOI
Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals
Matthew J. Kolar,Srihari Konduri,Tina Chang,Huijing Wang,Clare McNerlin,Lena Ohlsson,Magnus Härröd,Dionicio Siegel,Alan Saghatelian +8 more
TL;DR: 13-LAHLA is identified as an evolutionarily conserved lipid with anti-inflammatory activity in mammalian cells and suppresses lipopolysaccharide-stimulated secretion of cytokines and expression of pro-inflammatory genes.
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Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.
Dan Tan,Meric Erikci Ertunc,Srihari Konduri,Justin Zhang,Antonio F. M. Pinto,Qian Chu,Barbara B. Kahn,Dionicio Siegel,Alan Saghatelian +8 more
TL;DR: A mild alkaline hydrolysis method is developed that liberates FAHFAs from triacylglycerols for easier detection and reveals a new branch of TG and FAHFA metabolism with potential roles in metabolic health and regulation of inflammation.
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ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids
Rucha Patel,Anna Santoro,Peter Hofer,Dan Tan,Monika Oberer,Andrew T. Nelson,Srihari Konduri,Dionicio Siegel,Rudolf Zechner,Alan Saghatelian,Barbara B. Kahn +10 more
TL;DR: In this paper , the authors identified adipose triglyceride lipase (ATGL), also known as patatin-like phospholipase domain containing 2 (PNPLA2), as a candidate biosynthetic enzyme for FAHFAs using chemical biology and proteomics.
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Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis.
Srihari Konduri,Jyothi Prashanth,Vagolu Siva Krishna,Dharmarajan Sriram,J. N. Behera,Dionicio Siegel,Koya Prabhakara Rao +6 more
TL;DR: A series of novel purine linked piperazine derivatives were synthesized to identify new, potent inhibitors of Mycobacterium tuberculosis, designed to target MurB disrupting the biosynthesis of the peptidoglycan and exert antiproliferative effects.
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Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA
TL;DR: Reduction of the carbon chain lengths of the 9-hydroxystearic acid portion or palmitic acid hydrocarbon chain resulted in lower molecular weight analogs that maintained anti-inflammatory activity or in one case enhanced activity.