Srilakshmi Yalavarthi

TL;DR: Sera from patients with COVID-19 have elevated levels of cell-free DNA, myeloperoxidase(MPO)-DNA, and citrullinated histone H3 (Cit-H3); the latter two are highly specific markers of NETs, which may contribute to cytokine release and respiratory failure.

TL;DR: The results expand the potential pathogenic roles of aberrant lupus neutrophils and suggest that dysregulation of NET formation and its subsequent responses may play a prominent deleterious role.

TL;DR: Investigation of whether aberrant NETosis occurs in RA, determined its triggers, and examined its deleterious inflammatory consequences implicate accelerated NETosis in RA pathogenesis, through externalization of citrullinated autoantigens and immunostimulatory molecules that may promote aberrant adaptive and innate immune responses in the joint and in the periphery, and perpetuate pathogenic mechanisms in this disease.

TL;DR: It is demonstrated that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin, and that IL-23 and IL-1β can induce mast cell extracellular trap formation and degranulation of human mast cells.

TL;DR: Lupus LDGs are proinflammatory and display pathogenic features, including the capacity to synthesize type I IFNs, which may play an important dual role in premature cardiovascular disease development in systemic lupus erythematosus by simultaneously mediating enhanced vascular damage and inhibiting vascular repair.