Jeffrey B. Hodgin

TL;DR: The results expand the potential pathogenic roles of aberrant lupus neutrophils and suggest that dysregulation of NET formation and its subsequent responses may play a prominent deleterious role.

TL;DR: It is suggested that PAD inhibition can modulate phenotypes crucial for lupus pathogenesis and disease activity and may represent an important strategy for mitigating cardiovascular risk in lupu patients.

TL;DR: It is demonstrated that peptidylarginine deiminase (PAD) inhibition reduces NET formation and protects against lupus-related vascular damage in the New Zealand Mixed model of l upus.

TL;DR: The first genome-scale method to identify genes with cell-lineage-specific expression, even in lineages not separable by experimental microdissection is developed, which identified genes implicated as causal in hereditary glomerular disease and involved in molecular pathways of acquired and chronic renal diseases.

TL;DR: It is shown that a megacluster of nearly 40 microRNAs and their host long non-coding RNA transcript (lnc-MGC) are coordinately increased in the glomeruli of mouse models of DN, and mesangial cells treated with transforming growth factor-β1 (TGF- β1) or high glucose.