S
Srimathie Mukerji
Researcher at University of Saskatchewan
Publications - 7
Citations - 708
Srimathie Mukerji is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Lactic acid & Respiration. The author has an hindex of 7, co-authored 7 publications receiving 686 citations.
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Journal ArticleDOI
Lactate release from cultured astrocytes and neurons: A comparison
Wolfgang Walz,Srimathie Mukerji +1 more
TL;DR: It was found that insulin (1 μM) exposure mainly stimulated neuronal lactate release rather than glial release, and adenosine stimulated both neuronal and glialRelease, and neither intracellular lactate content nor concentration changed significantly in either cell type under any conditions tested.
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Kinetic characteristics of the glutamate uptake into normal astrocytes in cultures
TL;DR: The release of glutamate was much smaller than the uptake, and only little affected by an increase of the external glutamate concentration, suggesting a net accumulation of glutamate rather than a homoexchange, and may play a major role in brain metabolism and may keep the extracellular glutamate cohcentration below excitatory levels.
Journal ArticleDOI
Lactate production and release in cultured astrocytes.
Wolfgang Walz,Srimathie Mukerji +1 more
TL;DR: It is concluded that astrocytes produce substantial amounts of additional lactate during cytotoxic swelling, which is not increasing the intracellular osmolarity and most of the lactate is released into the extracellular space.
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KCl movements during potassium-induced cytotoxic swelling of cultured astrocytes.
Wolfgang Walz,Srimathie Mukerji +1 more
TL;DR: Astrocytes in primary cultures from mouse cortex were used to investigate the ionic mechanism of cytotoxic swelling which develops after exposure of the cells to 60 mM K+ under isosmotic conditions and it was found that the intracellular Cl- accumulation did not completely match the corresponding K+ accumulation.
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Simulation of aspects of ischemia in cell culture: changes in lactate compartmentation.
Wolfgang Walz,Srimathie Mukerji +1 more
TL;DR: It is concluded that lactate is released as lactic acid from astrocytes and equilibrates quickly with all CNS compartments, arguing against a role of lactate accumulation in cytotoxic swelling.