Stacey L. Dial

TL;DR: The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date.

TL;DR: If used in conjunction with phases I and II, which reduced the size of the data set dramatically by eliminating most inactive chemicals, the current CoMFA model can be used to predict the RBA of chemicals with sufficient accuracy and to provide quantitative information for priority setting.

TL;DR: The basal gene expression profiles of 251 drug-metabolizing enzymes in untreated primary human hepatocytes from six donors, four commonly used hepatoma cell lines, and one transfected human liver epithelial cell line are characterized, providing references for researchers to choose carefully appropriate in vitro models for studies of drug metabolism and toxicity.

TL;DR: SYBR Green real-time PCR delivers highly comparable results in gene expression measurement with TaqMan PCR and other high-density microarrays, and is evaluated in this study in terms of fold-change correlation and overlap of lists of differentially expressed genes.

TL;DR: Estrogen receptor relative binding affinities can be utilized before animal testing to rank order estimates of the potential for in vivo estrogenic activity of a wide range of untested plant chemicals (as well as other chemicals) based on ER binding.