The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands
R. Blair,Hong Fang,William S. Branham,Bruce S. Hass,Stacey L. Dial,Carrie L. Moland,Weida Tong,Leming Shi,Roger Perkins,Daniel M. Sheehan +9 more
TLDR
The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date.About:
This article is published in Toxicological Sciences.The article was published on 2000-03-01 and is currently open access. It has received 781 citations till now.read more
Citations
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Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
Gerald T. Ankley,Richard S. Bennett,Russell J. Erickson,Dale J. Hoff,Michael W. Hornung,Rodney D. Johnson,David R. Mount,John W. Nichols,Christine L. Russom,Patricia K. Schmieder,Jose A. Serrrano,Joseph E. Tietge,Daniel L. Villeneuve +12 more
TL;DR: A framework designed for this purpose, the adverse outcome pathway (AOP), is discussed, a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment.
Journal ArticleDOI
Safety assessment of esters of p-hydroxybenzoic acid (parabens)
TL;DR: The possible estrogenic hazard of parabens on the basis of the available studies is equivocal, and fails to consider the metabolism and elimination rates ofParabens, which are dose, route, and species dependent.
Journal ArticleDOI
Something from "nothing"--eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects.
TL;DR: It is concluded that estrogenic agents are able to act together to produce significant effects when combined at concentrations below their NOECs, highlighting the limitations of the traditional focus on the effects of single agents.
Journal ArticleDOI
In vitro and in vivo estrogenicity of UV screens.
Margret Schlumpf,Beata Cotton,Marianne Conscience,Vreni Haller,Beate Steinmann,Walter Lichtensteiger +5 more
TL;DR: The findings indicate that UV screens should be tested for endocrine activity, in view of possible long-term effects in humans and wildlife.
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Effect of endocrine disruptor pesticides: a review.
TL;DR: This paper reviews the current knowledge of the potential impacts of endocrine disruptor pesticides on human health and identifies several pesticides that pose a threat to human health.
References
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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
George G.J.M. Kuiper,Bo Carlsson,Kaj Grandien,Eva Enmark,Johan Häggblad,Stefan K. Nilsson,Jan-Åke Gustafsson +6 more
TL;DR: The messenger RNA expression of both ER subtypes in rat tissues by RT-PCR is investigated and the ligand binding specificity of the ER sub types is compared, revealing a single binding component for 16β-estradiol with high affinity.
Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Journal ArticleDOI
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
TL;DR: Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Journal ArticleDOI
Molecular basis of agonism and antagonism in the oestrogen receptor.
Andrzej M. Brzozowski,Ashley C. W. Pike,Zbigniew Dauter,Roderick E. Hubbard,Tomas Bonn,Owe Engström,Lars Öhman,Geoffrey L. Greene,Jan-Åke Gustafsson,Mats Carlquist +9 more
TL;DR: The crystal structures of the LBD of ER in complex with the endogenous oestrogen, 17β-oestradiol, and the selective antagonist raloxifene provide a molecular basis for the distinctive pharmacophore of the ER and its catholic binding properties.
Journal ArticleDOI
Molecular mechanisms of action of steroid/thyroid receptor superfamily members
Ming-Jer Tsai,Bert W. O'Malley +1 more
TL;DR: The role of Ligand in RECEPTOR TRANSFORMATION and ACTIVATION is studied, as well as the role of serotonin, which plays a role in both transformation and inhibition.