S
Stanisław Boryczka
Researcher at Medical University of Silesia
Publications - 93
Citations - 1042
Stanisław Boryczka is an academic researcher from Medical University of Silesia. The author has contributed to research in topics: Betulin & Quinoline. The author has an hindex of 16, co-authored 90 publications receiving 782 citations. Previous affiliations of Stanisław Boryczka include University of Silesia in Katowice & Free University of Berlin.
Papers
More filters
Journal ArticleDOI
Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.
Barbara Podeszwa,Halina Niedbala,Jaroslaw Polanski,Robert Musiol,Dominik Tabak,Jacek Finster,K. Serafin,Magdalena Milczarek,Joanna Wietrzyk,Stanisław Boryczka,W. Mol,Josef Jampilek,Jiří Dohnal,Danuta S. Kalinowski,Des R. Richardson +14 more
TL;DR: The structure-activity relationships of new quinoline based compounds were investigated and novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line but appeared far less efficient against SK-N-MC neuroepithelioma cells.
Journal ArticleDOI
Synthesis, structure and cytotoxic activity of new acetylenic derivatives of betulin.
Stanisław Boryczka,Ewa Bębenek,Joanna Wietrzyk,Katarzyna Kempińska,Maria Jastrzębska,Joachim Kusz,Maria Nowak +6 more
TL;DR: 28-O-Propynoylbetulin was the most potent derivative, being over 500 times more potent than betulin and about 100 times more cytotoxic than cisplatin against the human leukemia (CCRF/CEM) cell line, with an ID50 value of 0.02 μg/mL.
Journal ArticleDOI
Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis.
TL;DR: In this article, the potential evidence pointing ciprofloxacin and moxifloxacins ability to interact with COVID-19 Main Protease (Mpro) was presented.
Journal ArticleDOI
Novel triazoles of 3-acetylbetulin and betulone as anticancer agents.
TL;DR: The CuAAC reaction of azides and acetylenic triterpenes was used for synthesis of new triazoles of 3-acetylbetulin and betulone, which exhibited a significant IC50 value against the human glioblastoma SNB-19 cell line, an almost 5-fold higher potency while compared with reference cisplatin.
Journal ArticleDOI
Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile.
Ewa Bębenek,Maria Jastrzębska,Monika Kadela-Tomanek,Elwira Chrobak,Beata Orzechowska,Katarzyna Zwolińska,Małgorzata Latocha,Anna Mertas,Zenon P. Czuba,Stanisław Boryczka +9 more
TL;DR: A series of novel triazoles were prepared by the 1,3-dipolar cycloaddition reaction between the alkyne derivatives of betulin and organic azides and exhibited antibacterial activity against two gram-negative bacteria vz.