J
Jacek Finster
Researcher at University of Silesia in Katowice
Publications - 15
Citations - 474
Jacek Finster is an academic researcher from University of Silesia in Katowice. The author has contributed to research in topics: Quinoline & Lipophilicity. The author has an hindex of 8, co-authored 15 publications receiving 436 citations.
Papers
More filters
Journal ArticleDOI
Investigating biological activity spectrum for novel styrylquinazoline analogues.
Josef Jampilek,Robert Musiol,Jacek Finster,Matus Pesko,James Carroll,Katarina Kralova,Marcela Vejsova,Jim O'Mahony,Aidan Coffey,Jiri Dohnal,Jaroslaw Polanski +10 more
TL;DR: The structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds are described and the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs are illustrated.
Journal ArticleDOI
Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.
Barbara Podeszwa,Halina Niedbala,Jaroslaw Polanski,Robert Musiol,Dominik Tabak,Jacek Finster,K. Serafin,Magdalena Milczarek,Joanna Wietrzyk,Stanisław Boryczka,W. Mol,Josef Jampilek,Jiří Dohnal,Danuta S. Kalinowski,Des R. Richardson +14 more
TL;DR: The structure-activity relationships of new quinoline based compounds were investigated and novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line but appeared far less efficient against SK-N-MC neuroepithelioma cells.
Journal ArticleDOI
Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity.
Robert Musiol,Dominik Tabak,Halina Niedbala,Barbara Podeszwa,Josef Jampilek,Katarina Kralova,Jiri Dohnal,Jacek Finster,Agnieszka Mencel,Jaroslaw Polanski +9 more
TL;DR: Two series of amides based on quinoline scaffold showed biological activity similar or even higher than that of the standard (DCMU) and the structure-activity relationships are discussed.
Journal ArticleDOI
Ring-substituted 4-hydroxy-1H-quinolin-2-ones: preparation and biological activity.
Josef Jampilek,Robert Musiol,Matus Pesko,Katarina Kralova,Marcela Vejsova,James Carroll,Aidan Coffey,Jacek Finster,Dominik Tabak,Halina Niedbala,Violetta Kozik,Jaroslaw Polanski,Jozef Csöllei,Jiri Dohnal +13 more
TL;DR: In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared and the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).
Journal ArticleDOI
Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones.
Anna Mrozek-Wilczkiewicz,Danuta S. Kalinowski,Robert Musiol,Jacek Finster,Agnieszka Szurko,K. Serafin,Magdalena Knas,Sishir K Kamalapuram,Zaklina Kovacevic,Josef Jampilek,Alicja Ratuszna,Joanna Rzeszowska-Wolny,Des R. Richardson,Jaroslaw Polanski +13 more
TL;DR: Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin.